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31 August 2019 : Clinical Research  

Upregulation of Long Non-Coding RNA ENST00000429227.1 Is Correlated with Poor Prognosis in Human Hepatocellular Carcinoma

Yuan Zhao1BE, Cun-Qing Kong2C, Jia-Zhou Ye1F, Tao Bai1D, Tao Luo1BF, Duo Wang3C, Miao Chen3F, Hui-Feng Wang1DF, Xiao-Bo Wang1D, Jun-Jie Liu3B, Jie Chen1F, Hong-Lin Luo1AF*, Le-Qun Li1AG

DOI: 10.12659/MSM.916551

Med Sci Monit 2019; 25:6539-6546

Abstract

BACKGROUND: Long non-coding RNAs (lncRNAs) have been shown to play an important regulatory role in many tumors. This study was designed to investigate the expression of lncRNA ENST00000429227.1 in hepatocellular carcinoma (HCC) and to determine whether the expression of lncRNA ENST00000429227.1 affects the prognosis of HCC.

MATERIAL AND METHODS: lncRNA ENST00000429227.1 showing differences in expression between M1 and M2 was screened by microarray expression measurements. Quantitative real-time PCR (qRT-PCR) was used to detect the expression of lncRNA ENST00000429227.1 in 161 HCC patients. The chi-square test was used to evaluate the relationship between the expression of ENST00000429227.1 and clinicopathological parameters. A survival curve was drawn and analyzed by Kaplan-Meier method. Cox regression was used for univariate and multivariate analysis to determine whether lncRNA ENST00000429227.1 is an independent factor of the occurrence and prognosis of HCC.

RESULTS: A total of 3703 differentially expressed lncRNAs were obtained, of which 1777 were upregulated and 1926 were downregulated, with multiple change >1.5. The expression of lncRNA ENST00000429227.1 was upregulated in M2 cells. The expression of lncRNA ENST00000429227.1 in HCC tissues was higher than that in adjacent normal tissues (p<0.05), which was correlated with pathological parameters such as surgical margin (p=0.042), AFP (p=0.022) and Barcelona Clinic Liver Cancer (BCLC) stage (p=0.008). Survival analysis showed that high expression of lncRNA ENST00000429227.1 was associated with a decrease in overall survival (OS) rate of HCC patients. Cox regression analysis showed that high expression of ENST00000429227.1 may be an independent risk factor affecting the prognosis of HCC patients.

CONCLUSIONS: The results suggest that upregulation of ENST00000429227.1 is associated with poor prognosis of HCC patients, and may be a new biomarker for the diagnosis of HCC.

Keywords: Carcinoma, Hepatocellular, Prognosis, RNA, Long Noncoding, Gene Expression Regulation, Neoplastic, Liver Neoplasms, Middle Aged, Multivariate Analysis, Proportional Hazards Models, Survival Analysis, Up-Regulation

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750