Postoperative Serum Levels of Interleukin-1β (IL-1β), Interleukin-17 (IL-17), and Tumor Necrosis Factor-α (TNF-α) in Patients Following Hip Replacement Surgery for Traumatic Fractured Femoral Neck: A Retrospective Study
Hui Zhang, Huiping Tai, Yuhong Ma, Yan Li, Zongping Dang, Junkai Wang, Lin Zhao
Department of Orthopedics, Gansu Provincial Hospital West Campus, Lanzhou, Gansu, China (mainland)
Med Sci Monit 2019; 25:6120-6127
This study aimed to investigate the clinical significance of postoperative serum levels of interleukin-1ß (IL-1ß), interleukin-17 (IL-17), and tumor necrosis factor-alpha (TNF-alpha) in patients who required hip replacement surgery for traumatic fractured neck of femur.
MATERIAL AND METHODS: A retrospective study included 180 patients who had hip replacement surgery for traumatic fractured neck of femur and a control group of 100 patients. Differences between the two groups were compared for serum levels of IL-1ß, IL-17, and TNF-alpha, and the Harris Hip Score (HHS) (maximum 100 points) using Pearson’s correlation.
RESULTS: Serum levels of IL-1ß, IL-17, and TNF-alpha in the control group were significantly lower than those in the study group (P<0.05). According to the HHS, there were 53 patients in the excellent group, 65 patients in the good group, 43 patients in the fair group and 19 patients in the poor group. Postoperative indicator analysis showed significant differences in IL-1ß, IL-17, and TNF-alpha levels between the four groups (P<0.05). Clinical indicators increased from the excellent group to the poor group, with significant differences between the four groups (P<0.05). Postoperative levels of IL-1ß, IL-17, and TNF-alpha were significantly decreased (P<0.05). Pearson’s correlation analysis showed a significant correlation with the clinical indicators (P<0.05).
CONCLUSIONS: In patients with hip replacement surgery for traumatic fractured neck of femur, measurement of postoperative serum levels of IL-1ß, IL-17, and TNF-alpha were shown to be potential prognostic indicators.
Keywords: Interleukin-1beta, Receptors, Interleukin-17, Tumor Necrosis Factor-alpha