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08 January 2019 : Clinical Research  

Effects of Intermittent Parathyroid Hormone 1–34 Administration on Circulating Mesenchymal Stem Cells in Postmenopausal Osteoporotic Women

Yutao Tang1ACE, Han Xia1B, Liang Kang1F, Quan Sun1D, Zhe Su1G, Congqiang Hao1F, Yuan Xue1AG*

DOI: 10.12659/MSM.913752

Med Sci Monit 2019; 25:259-268


BACKGROUND: Intermittent parathyroid hormone (PTH) 1–34 administration stimulates osteogenesis and increases bone marrow mesenchymal stem cell (MSC) density; however, its effect on the circulating MSCs is unknown. This study aimed to examine the effect of intermittent PTH 1–34 administration on circulating MSCs in the peripheral blood of postmenopausal osteoporotic women.

MATERIAL AND METHODS: Fifty-four postmenopausal osteoporotic women at high risk of fracture were enrolled and administered either teriparatide (PTH 1–34) or alendronate for 12 months. Whole blood samples were obtained at baseline, 1, 3, 6, and 12 months after initiation of treatment. Flow cytometry analyses were performed to identify circulating MSCs (CD73+, CD90+, CD105+, CD34−, and CD45−). Serum markers of bone formation, bone resorption, as well as bone mineral density (BMD) were serially measured. Circulating MSCs were isolated from peripheral blood of teriparatide treated women and cultured in osteogenic medium to examine their osteogenic differentiation potential.

RESULTS: Teriparatide treatment increased circulating MSCs to 141±96% (P<0.001) by month 1, persisting until month 12; this increase was positively associated with increases in bone formation and bone resorption biomarkers (at month 6) and spine BMD (at month 12). Furthermore, intermittent PTH 1–34 administration promoted in vitro osteogenic differentiation of circulating MSCs, evident from increased alkaline phosphatase (ALP) activity, ALP-expressing cell density, calcium deposition, and Runx-2, OSX, COL 1a1, and osteocalcin mRNA upregulation.

CONCLUSIONS: Intermittent PTH 1–34 administration increased circulating MSC density in women with postmenopausal osteoporosis and enhanced in vitro osteogenic differentiation potential of these cells.

Keywords: alendronate, mesenchymal stromal cells, Osteoporosis, Postmenopausal, Parathyroid Hormone



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Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients

Dinah V. Parums
Science Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750