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eISSN: 1643-3750

LINK-A Long Non-Coding RNA (lncRNA) Participates in Metastasis of Ovarian Carcinoma and Upregulates Hypoxia-Inducible Factor 1 (HIF1α)

Huijun Zhang, Bin Yao, Shengchun Tang, Ying Chen

Department of Obstetrics and Gynecology, Xiangyang Central Hospital, Affiliated Hospital of Hubei University of Arts and Science, Xiangyang, Huibei, China (mainland)

Med Sci Monit 2019; 25:2221-2227

DOI: 10.12659/MSM.913609

Available online:

Published: 2019-03-26

BACKGROUND: The functionality of LINK-A lncRNA as an oncogenic lncRNA has only been characterized in triple-negative breast cancer. The present study investigated the possible involvement of LINK-A in ovarian carcinoma.
MATERIAL AND METHODS: We enrolled 76 patients with ovarian carcinoma. Quantitative real-time PCR (qRT-PCR) was performed to analyze LINK-A expression in ovarian biopsies. Effects of LINK-A overexpression on HIF1alpha and cancer cell migration and invasion were assessed.
RESULTS: We found that LINK-A was significantly higher in ovarian carcinoma patients than in healthy controls in ovarian biopsies and in serum. LINK-A expression effectively distinguished patients with metastatic ovarian carcinoma from healthy controls. LINK-A overexpression promoted cancer cell migration and invasion, and also upregulated the expression of HIF1alpha.
CONCLUSIONS: LINK-A lncRNA may be involved in the metastasis of ovarian carcinoma by upregulating HIF1alpha.

Keywords: Diagnostic and Statistical Manual of Mental Disorders, Ovarian Neoplasms, RNA, Long Noncoding, Up-Regulation