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09 April 2019 : Clinical Research  

Construction and Analysis of lncRNA-Mediated ceRNA Network in Cervical Squamous Cell Carcinoma by Weighted Gene Co-Expression Network Analysis

Weihao Chen1CDEF, Xudong Chen1BEF, Yurong Wang1ABC, Tianhao Liu1EF, Yudan Liang12AB, Ya Xiao1EFG*, Liguo Chen1EFG

DOI: 10.12659/MSM.913471

Med Sci Monit 2019; 25:2609-2622

Abstract

BACKGROUND: More and more recent studies have clearly shown that long non-coding RNA (lncRNA) should be considered as a fundamental part of the ceRNA network, mainly because lncRNA can act as miRNA sponges to regulate the protein-coding gene expression. Nevertheless, it is still not clear how lncRNA-mediated ceRNAs function in cervical squamous cell carcinoma (CESC). Moreover, information about the ceRNA regulatory mechanism is also remarkably limited; thus, prediction of CESC prognosis using ceRNA-related information remains challenging.

MATERIAL AND METHODS: We collected 306 RNA (lncRNA, miRNA, and mRNA) expression profile datasets obtained from cervical squamous cancer tissues plus 3 more from adjacent cervical tissues via the TCGA database. Subsequently, we constructed a lncRNAs-miRNAs-mRNAs CESC ceRNA network, and Gene Ontology (GO) analysis was carried out.

RESULTS: We identified a total of 30 DElncRNAs, 70 DEmiRNAs, and 1089 DEmRNAs in CESC. Subsequently, to reveal the expression patterns of dysregulated genes, weighted gene co-expression network analysis was carried out, resulting in 3 co-expression modules with significantly related clinical properties. The constructed aberrant lncRNAs-miRNAs-mRNAs CESC ceRNA network was composed of 17 DEmiRNAs, 5 DElncRNAs, and 7 DEmRNAs. Moreover, the survival analysis was performed for DElncRNAs, DEmiRNAs, and DEmRNAs.

CONCLUSIONS: The present study shows the involvement of the lncRNA-related ceRNA network in the pathogenesis of CESC. We believe the newly generated ceRNA network will provide more insights into the lncRNA-mediated ceRNA regulatory mechanisms.

Keywords: Genes, Neoplasm, Genes, rRNA, Genes, vif, Uterine Cervical Neoplasms, Carcinoma, Squamous Cell, Gene Expression Regulation, Neoplastic, gene ontology, Gene Regulatory Networks, Kaplan-Meier Estimate, MicroRNAs, Middle Aged, Protein Interaction Maps, RNA, Long Noncoding, RNA, Messenger, RNA, Neoplasm

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750