01 February 2019 : Clinical Research
Increased Serum CA125 and Brain-Derived Neurotrophic Factor (BDNF) Levels on Acute Myocardial Infarction: A Predictor for Acute Heart FailureHaibo Wu1AB, Guangyun Cao1ADE, Yuncan Wang2EG, Huanping Tian1CDE, Rongpin Du1BCF*
Med Sci Monit 2019; 25:913-919
BACKGROUND: This study was conducted to see whether increased values of serum CA125 and BDNF (brain-derived neurotrophic factor) on acute myocardial infarction (AMI) act as predictor for acute heart failure (AHF).
MATERIAL AND METHODS: Seventy-eight patients with clinically diagnosed cardiac function II–IV; and AHF were considered as the study group of this retrospective study and patients who had cardiac function I (without AHF) were considered the control group (n=82). The values of CA125 and BDNF were measured using enzyme-linked immunosorbent assay (ELISA) for developing the correlation with the Killip classification, and the diagnostic value of AHF.
RESULTS: Statistically insignificant difference was noticed between baseline information e.g., blood pressure or smoking status of participants in study group and control group (P>0.05). The higher values of CA125 (5.68±1.8 U/mL or BDNF (19.48±5.3 pg/mL) in the study group had advantage over the control after independent sample t-test (P<0.001). A positive correlation was observed between values of the test substances and Killip classifications (I-IV) of cardiac functioning was observed (r=0.745, P<0.001; Spearman’s rank correlation coefficient). The sensitivity and specificity of area under the curve (AUC) combined with serum CA125 and BDNF levels in the diagnosis of AHF was 91.02% and 81.63%, respectively.
CONCLUSIONS: Increased serum level of the test substances indicates severity of AHF-leading AMI. Thus, monitoring is needed to avoid risk of AHF.
Keywords: Anterior Wall Myocardial Infarction, Diagnostic Test Approval, Prostatitis, Acute Disease, Aged, Aged, 80 and over, biomarkers, Brain-Derived Neurotrophic Factor, CA-125 Antigen, Heart Failure, Male, Membrane Proteins, Middle Aged, Myocardial Infarction, Natriuretic Peptide, Brain, Peptide Fragments, Prognosis, Prospective Studies, Retrospective Studies, Risk Factors
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