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23 December 2018 : Clinical Research

Clinical Features and Prognostic Factors in Elderly Ewing Sarcoma Patients

Hua-Fei Liu12ABCDEF, Ji-Xin Wang3BCD, Dong-Quan Zhang3BCE, Si-Heng Lan3BF, Qi-Xin Chen4ABCDEF*

DOI: 10.12659/MSM.911882

Med Sci Monit 2018; 24: CLR9370-9375

Abstract

BACKGROUND: Elderly patients with Ewing sarcoma have a very poor prognosis, and treatment remains a challenge. However, the outcomes and potential prognostic factors of elderly Ewing sarcoma patients are rarely documented. Therefore, we investigated the prognosis of this special cohort and determine independent prognostic factors.

MATERIAL AND METHODS: A cohort of Ewing sarcoma patients aged over 40 years from 1973 to 2015 was identified from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database. The Kaplan-Meier method and a Cox proportional hazard regression model were used for the prognostic analysis.

RESULTS: A total of 162 patients were included with a mean age of 53 years. The 5-year overall survival (OS) and cancer-specific survival (CSS) rates of the entire group were 43.7% and 47.9%, respectively. The sex, location, tumor size, and radiation treatment had no effect on survival outcomes on univariate analysis. Tumor stage, surgery, and chemotherapy were significant indicators of both OS and CSS on multivariable analysis.

CONCLUSIONS: Surgery in combination with chemotherapy had a significant survival benefit in elderly Ewing sarcoma patients and should be recommended.

Keywords: Adult, Prognosis, Sarcoma, Ewing

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750