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Medical Science Monitor Basic Research


eISSN: 1643-3750

Clinical Features and Prognostic Factors in Elderly Ewing Sarcoma Patients

Hua-Fei Liu, Ji-Xin Wang, Dong-Quan Zhang, Si-Heng Lan, Qi-Xin Chen

Department of Orthopaedics, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China (mainland)

Med Sci Monit 2018; 24: CLR9370-9375

DOI: 10.12659/MSM.911882

Available online: 2018-12-23

Published: 2018-12-23


BACKGROUND: Elderly patients with Ewing sarcoma have a very poor prognosis, and treatment remains a challenge. However, the outcomes and potential prognostic factors of elderly Ewing sarcoma patients are rarely documented. Therefore, we investigated the prognosis of this special cohort and determine independent prognostic factors.
MATERIAL AND METHODS: A cohort of Ewing sarcoma patients aged over 40 years from 1973 to 2015 was identified from the National Cancer Institute’s Surveillance, Epidemiology, and End Results (SEER) database. The Kaplan-Meier method and a Cox proportional hazard regression model were used for the prognostic analysis.
RESULTS: A total of 162 patients were included with a mean age of 53 years. The 5-year overall survival (OS) and cancer-specific survival (CSS) rates of the entire group were 43.7% and 47.9%, respectively. The sex, location, tumor size, and radiation treatment had no effect on survival outcomes on univariate analysis. Tumor stage, surgery, and chemotherapy were significant indicators of both OS and CSS on multivariable analysis.
CONCLUSIONS: Surgery in combination with chemotherapy had a significant survival benefit in elderly Ewing sarcoma patients and should be recommended.

Keywords: Adult, Prognosis, Sarcoma, Ewing