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eISSN: 1643-3750

Study on the Significance of Folate Receptor-Mediated Staining Solution (FRD) Staining in Screening High Grade Cervical Lesions

Songshu Xiao, Hui Xie, Xiaogang Zhu, Xiang Li, Shuijing Yi, Xingliang Deng, Min Xue

Department of Gynecology and Obstetrics, The Third Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland)

Med Sci Monit 2019; 25:2792-2801

DOI: 10.12659/MSM.911402

Available online:

Published: 2019-04-16


BACKGROUND: The aim of this study was to investigate the significance of folate receptor-mediated staining solution (FRD) in examination of cervical lesions during gynecological examination.
MATERIAL AND METHODS: A total of 404 patients participated in this study. FRD staining was applied to screen high grade cervical lesions. ThinPrep cytology test (TCT) and human papillomavirus (HPV) testing were also used for screening high grade cervical lesions. Coincidence rate and KAPPA value of different methods were compared by SPSS software.
RESULTS: As for CIN2+ and CIN3+, sensitivities for HPV testing were (96.92% and 97.78%) >TCT classification 1 (90.77% and 91.11%) >FRD staining (80.00% and 86.67%) >TCT classification 2 (70.77% and 77.78%), respectively. While specificities for HPV testing were (7.08% and 6.44%) <TCT classification 1 (39.53% and 37.88%) <FRD staining (51.92% and 50.97%) <TCT classification 2 (70.80% and 69.36%), respectively. Coincidence rate and KAPPA value of FRD staining, TCT classification 1, TCT classification 2, and HPV testing for detecting CIN2+ results were 56.44% and 16.52%, 47.77% and 13.54%, 70.79% and 27.76%, and 21.53% and 1.36%, respectively. Coincidence rate and KAPPA value of FRD staining, TCT classification 1, TCT classification 2, and HPV testing versus CIN3+ results were 54.95% and 14.19%, 43.81% and 9.27%, 70.30% and 23.91%, and 17.08% and 1.12%, respectively.
CONCLUSIONS: FRD staining was capable of detecting cervical lesions rapidly and is a cost-effective method for routine cervical lesions screening.

Keywords: 3T3 Cells, DNA Probes, HPV, I-kappa B Proteins, Silver Staining



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