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17 November 2018 : Clinical Research

A Clinical Prognostic Score to Predict Survival of Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) Patients Receiving First-Line Chemotherapy: A Retrospective Analysis

Jing Gong12ABCDEF, Ling Xu12ABCDEF, Zhi Li12AC, Xuejun Hu3B, Jing Liu12B, Yuee Teng12B, Bo Jin12B, Mingfang Zhao12B, Jing Shi12B, Tianshu Guo12BDEF, Xiaonan Shi12BCDF, Yu Cheng12EFG, Yunpeng Liu12AB*, Xiujuan Qu12AG

DOI: 10.12659/MSM.911026

Med Sci Monit 2018; 24: CLR8264-8271

Abstract

BACKGROUND: Although several complicated models have been built to evaluate the prognosis of NSCLC patients receiving chemotherapy, simple economic models are still needed to give a preliminary survival assessment of these patients.

MATERIAL AND METHODS: This study retrospectively assessed the clinical and biological parameters of 223 patients with advanced NSCLC. Univariate and multivariate analyses of overall survival (OS) and progression-free survival (PFS) for the parameters and the prognostic score were assessed.

RESULTS: Performance status (PS) score=1, smoking history, fibrinogenemia, thrombocytosis, increased lactate dehydrogenase (LDH) level, and anemia were independent predictors of poor prognosis in the univariate analysis of OS and were assessed in multivariate analysis. There was a significant difference in PS=1 (HR=2.134, p<0.0001), increased LDH level (HR=1.508, p=0.014), thrombocytosis (HR=1.547, p=0.012), and smoking history (HR=1.491, p=0.008), based on which the patients were classified into 3 risk groups: low risk (0–1 points), moderate risk (2 points), and high risk (3–5 points). At p values of <0.0001, the median OS was 565, 340, and 273 days and the median progression-free survival was 250, 209, and 135 days, respectively in these 3 risk groups.

CONCLUSIONS: We established a new prognostic score model using PS, LDH level, PLT count, and smoking history to predict the survival of patients receiving first-line chemotherapy for advanced NSCLC, which might be useful in clinical practice.

Keywords: Lung Neoplasms, Overall, Prognosis, Survival

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750