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07 June 2018 : Laboratory Research  

Serum Inflammatory Markers in Patients with Adenovirus Respiratory Infection

Junping Sun1ABCDEFG, Yongjiu Xiao1BC, Mingyue Zhang1BCF, Ting Ao1EF, Shan Lang1BCF, Jianxin Wang1ADG*

DOI: 10.12659/MSM.910692

Med Sci Monit 2018; 24: LBR3848-3855


BACKGROUND: The aim of this study was to characterize adenovirus-associated acute respiratory infection (ARI) and observe correlations between inflammatory markers and severity of human adenovirus type 7 (HAdV-7) infection, and to evaluate the potential of inflammatory markers to predict progression from upper-respiratory infection (URI) to adenovirus pneumonia (AdP).

MATERIAL AND METHODS: A total of 81 patients with adenovirus-associated ARI and confirmed HAdV-7 infection were enrolled. Cases were classified according to severity, as AdP and URI. Demographic and clinical data were collected retrospectively. Clinical features and serum inflammatory markers were evaluated and compared according to the severity of adenoviral infection.

RESULTS: We observed high-grade fever and strong inflammatory response in patients with HAdV-7–associated ARI. Procalcitonin (PCT), interleukin 6 (IL-6), and C-reactive protein concentrations were higher in patients with AdP than in those with URI. The mean erythrocyte sedimentation rate (ESR) was significantly higher in patients with AdP (p=0.008). Reduced serum prealbumin levels were observed in patients with HAdV-7 infection. In the analysis of URI to AdP prediction ability, areas under the curve (AUCs) for all inflammatory markers were <0.9. We found that 35.9% of pneumonia had ≥2 lobars of lung infiltrate and bilateral lung infiltrate, and 20% of patients with SP had pleural effusion and atelectasis.

CONCLUSIONS: IL-6 and ESR were associated with the severity of HAdV-7 respiratory infection. No inflammatory marker in our study predicted URI-to-AdP progression accurately. Lung infiltration and consolidation are common in HRCT in AdP. Multiple- or single-lobar/segment consolidation was most common in SP. SP progressed very quickly after onset.

Keywords: Adenovirus Infections, Human, Respiratory System, Systemic Inflammatory Response Syndrome



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Dinah V. Parums
Scientific Editor, Medical Science Monitor, International Scientific Information, Inc., Melville, NY, USA

DOI: 10.12659/MSM.935624

Med Sci Monit 2021; 27:e935624


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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750