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17 December 2018 : Original article  

Interrelationship Between Markers of Oxidative Stress, Inflammation and Hematological Parameters Among Preeclamptic Nigerian Women

Oloruntoba Ayodele Ekun1ABCDEFG*, Nkeiruka Ogochukwu Ogidi1BDEFG, Rukayat Adetutu Lawal1BCEFG, Olumuyiwa Adeniran Ogunmuyiwa1BCEFG, Mirian Chiamaka Umewune1ABCDEFG, Florence Oreitan Adefolaju23BDEG, Mary Foluke Oshundun1CDFG, Ayoola Islamiyat Oremosu14DEFG

DOI: 10.12659/MSMBR.910660

Med Sci Monit Basic Res 2018; 24:225-231

Abstract

BACKGROUND: Preeclampsia is a multifaceted pregnancy-related disorder affecting women and fetuses. A link between preeclampsia, oxidative stress, and inflammation has been suggested. This study evaluated the interrelationship between biomarkers of oxidative stress, inflammation, and hematological parameters among preeclamptic Nigerian women.

MATERIAL AND METHODS: A cross-sectional study was conducted among 49 preeclamptic and 50 normotensive healthy pregnant women. Blood samples were obtained after 20-week gestation in all participants. Levels of superoxide dismutase (SOD), catalase, glutathione (GSH), malonaldehyde (MDA), total protein, high-sensitivity C-reactive protein (hs-CRP), and cardiac-specific troponin I (cTnI) were determined by spectrophotometric and ELISA techniques. FBC, prothrombin time, and activated partial thromboplastin time were determined using an auto-analyzer, Quick’s one-stage, and Proctor’s and Rappaport’s modification methods, respectively.

RESULTS: The mean SOD (0.051±0.050 vs. 0.073±0.047, p 0.029), catalase (2.62±1.93 vs. 8.48±4.40, p<0.001), GSH (49.05±17.57 vs. 187.10±56.07 p<0.001), platelet (127.63±89.75 vs. 267.16±212.82, p<0.001 were lower in preeclampsia. MDA (7.16±5.00 vs. 2.91±2.66, p<0.001), cTnI (0.46±0.31 vs. 0.13±0.14 p<0.001), PT (19.36±4.06 vs. 13.45±1.97 p<0.001), APTT (45.53±2.92 vs. 37.49±4.99; p<0.001) were higher in preeclampsia. Negative associations between SOD and MDA (r –0.527 p<0.001), CAT and MDA (r –0.469, p 0.001) and positive associations between catalase and hs-CRP (r 0.844, p 0.029), RBC and HB (r 0.442, p 0.001), platelet, and SOD (r 0.353, p 0.013) were observed among preeclamptic volunteers.

CONCLUSIONS: Preeclampsia is associated with oxidative stress, derangement of hematological and coagulation homeostasis, as well as deleterious effects on the cardiovascular system.

Keywords: Blood Coagulation Tests, Pre-Eclampsia, troponin I

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Medical Science Monitor Basic Research eISSN: 2325-4416
Medical Science Monitor Basic Research eISSN: 2325-4416