Clinical Features of 167 Inpatients with Autosomal Dominant Polycystic Kidney Disease at a Single Center in China
Jialin Meng, Yuchen Xu, Ao Li, Song Fan, Xufeng Shen, Dongyue Ma, Li Zhang, Zongyao Hao, Xiansheng Zhang, Chaozhao Liang
(Anhui Province PKD Center, Institute/Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China (mainland))
Med Sci Monit 2018; 24:6498-6505
The aim of this study was to describe the clinical characteristics of Chinese ADPKD inpatients and to identify the factors associated with disease severity.
MATERIAL AND METHODS: We included 167 hospitalized patients (inpatients) with ADPKD in this study. Multiple regression analyses were conducted to determine factors correlated with estimated glomerular filtration rate (eGFR). Patients were stratified into subgroups according to the presence of symptoms, in which clinical parameters were analyzed and compared.
RESULTS: The mean age of hospitalized ADPKD patients was 48.7 years old, lumbar and/or abdominal pain was seen in 40.12% of patients, following by nephrolithiasis (38.92%), hematuria (30.54%), and urinary tract infection (24.55%). Serum thrombocyte level and hemoglobin exhibited significant positive correlations with eGFR. Symptomatic patients accounted for 71.26% of the studied population. Patients with hypertension had increased risk of presence of symptoms (OR=2.794, 95%CI=1.341–5.822). Low thrombocyte and hemoglobin levels were observed in patients with hematuria.
CONCLUSIONS: Thrombocyte level was positively correlated with eGFR but was not associated with presence of PKD-related symptoms, suggesting thrombocyte level might be an independent serum biomarker for disease progression. Hypertension was associated with increased risk of symptom occurrence, indicating the relationship between hypertension and disease progression. This study reveals the clinical characteristics of inpatients with ADPKD in China and provides clinicians with useful insights into this intractable disease.
Keywords: Signs and Symptoms, Glomerular Filtration Rate, Polycystic Kidney, Autosomal Dominant, Urologic Surgical Procedures