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03 June 2018 : Laboratory Research  

Elevated Transient Receptor Potential Melastatin 8 (TRPM8) Expression Is Correlated with Poor Prognosis in Pancreatic Cancer

Jun-dong Du1AB, Xi Zheng2AB, Yong-liang Chen3FG*, Zhi-qiang Huang3FG, Shou-wang Cai3CD, Hua-bo Jiao1EF, Zi-man Zhu1EF, Bin Hu1DEF

DOI: 10.12659/MSM.909968

Med Sci Monit 2018; 24: LBR3720-3725

Abstract

BACKGROUND: The transient receptor potential melastatin 8 (TRPM8) was found to be expressed abnormally in a variety of tumors and is associated with unfavorable prognosis in human cancers. However, its clinical significance in pancreatic cancer (PC) is mostly unknown.

MATERIAL AND METHODS: qRT-PCR was performed to measure the expression of TRPM8 in 110 pairs of PC tissues and the adjacent non-cancerous tissues. The association of TRPM8 expression with the clinical characters of PC patients was analyzed using the chi-square test. Furthermore, the prognostic value of TRPM8 was determined with Kaplan-Meier survival curve and Cox regression analysis.

RESULTS: We found that the expression level of TRPM8 was significantly elevated in PC tissues compared to the non-cancerous controls (P<0.001). In addition, a close relationship was observed between elevated TRPM8 expression with large tumor size (P=0.001), advanced TNM (P=0.013), and distant metastasis (P=0.034). Survival analysis suggested that patients with high TRPM8 expression has worse OS (P=0.001) and DFS (P<0.001) than those with low TRPM8 expression. Moreover, TRPM8 was confirmed as a valuable prognostic biomarker for OS (HR=1.913; 95% CI: 1.020–3.589; P=0.043) or DFS (HR=2.374; 95% CI: 1.269–4.443; P=0.007) of PC patients.

CONCLUSIONS: This study shows that TRPM8 expression is significantly up-regulated in PC and it might be a useful prognostic factor for patients with PC.

Keywords: Biological Markers, Prognosis, Transient Receptor Potential Channels

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750