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Medical Science Monitor Basic Research


eISSN: 1643-3750

Association of Periodontitis with Rheumatoid Arthritis and the Effect of Non-Surgical Periodontal Treatment on Disease Activity in Patients with Rheumatoid Arthritis

Xinyuan Zhao, Zhongjun Liu, Dalong Shu, Yanlin Xiong, Minzhao He, Shuaimei Xu, Shanhan Si, Bing Guo

Department of Dentistry, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, China (mainland)

Med Sci Monit 2018; 24: CLR5802-5810

DOI: 10.12659/MSM.909117

Available online:

Published: 2018-08-20


BACKGROUND: The association of periodontitis (PD) with the prevalence of rheumatoid arthritis (RA) remains controversial. Therefore, the aim of this study was to evaluate their correlation and investigate the effects of non-surgical periodontal treatment on RA.
MATERIAL AND METHODS: A total of 64 patients were enrolled in this study and divided into 4 groups: 18 PD patients (PD+RA–), 18 RA patients (PD–RA+), 18 RA with PD patients (PD+RA+), and 10 healthy controls (PD–RA–). Periodontal and rheumatologic parameters were examined at baseline and 1 month following non-surgical periodontal treatment.
RESULTS: Our results showed that RA patients had similar periodontal status. However, patients in the PD+RA+ group had significantly higher levels of rheumatologic parameters such as C-reactive protein (CRP), anti-cyclic citrulline peptide antibody (ACPA), erythrocyte sedimentation rate (ESR), and Disease Activity Score 28 (DAS28) than those in the PD-RA+ group. In addition, non-surgical periodontal treatment was efficacious in improving rheumatologic parameters of patients in the PD+RA+ group.
CONCLUSIONS: The presence of PD might contribute to the progression of RA, while RA might have little effect on accelerating the development of PD. In addition, RA patients with PD receiving non-surgical periodontal treatment resulted in noteworthy improvement in the clinical outcome for RA.

Keywords: Arthritis, Rheumatoid, chronic periodontitis, Disease Progression