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Treatment Outcomes and Prognostic Factors of Adult Sinonasal Sarcomas: A Single-Institution Case Series

Jianming Ding, Cuihong Wang, Jun Xiang, Chunying Shen, Chaosu Hu, Tingting Xu, Xueguan Lu

Department of Radiation Oncology, Fudan University Shanghai Cancer Center, Shanghai, China (mainland)

Med Sci Monit 2018; 24:6113-6118

DOI: 10.12659/MSM.909116

Available online:

Published: 2018-09-02

BACKGROUND: The purpose of this study was to investigate the treatment outcomes and evaluate the prognostic factors of adult sinonasal sarcomas.
MATERIAL AND METHODS: A retrospective review was performed on consecutive patients with adult sinonasal sarcomas treated in our institution from 2005 to 2016. The Kaplan-Meier method was used to evaluate local recurrence-free survival (LRFS), distant metastases-free survival (DMFS), and overall survival (OS). Univariate and multivariate analyses using Cox proportional hazard models were performed to determine the prognostic factors associated with survival outcomes.
RESULTS: A total of 49 patients were followed up for 6–122 months, with a median time of 36 months. The 5-year LRFS, DMFS, and OS rates of all patients were 68.3%, 62.8%, and 43.2%, respectively. The results of univariate analysis revealed that patients with an advanced stage of primary tumor and those who received incomplete surgical resection had worse LRFS (p=0.013; p=0.026). Patients with the histological type rhabdomyosarcoma (RMS) and existing regional lymph node metastasis had worse DMFS (p=0.000; p=0.001). The histological type RMS, advanced stage of primary tumor, existing regional lymph node metastasis, and receiving incomplete surgical resection had an unfavorable effect on OS (p=0.001; p=0.002; p=0.008; p=0.011). The results of multivariate analysis showed that histological type and degree of surgical resection were the independent prognostic factors for OS.
CONCLUSIONS: Our results suggest that the histological type RMS and receiving incomplete surgical resection are independent prognostic factors for worse OS.

Keywords: Adult, Prognosis, Rhabdomyosarcoma, Sarcoma