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22 February 2018 : Laboratory Research  

Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain

Zhenhua Shi1ABCEG, Wusi Qiu1ACD, Guomin Xiao1ADF, Jun Cheng1ABF, Ning Zhang2ABCDEFG

DOI: 10.12659/MSM.909042

Med Sci Monit 2018; 24: LBR1097-1103

Abstract

BACKGROUND: Traumatic brain injury (TBI) is characterized by cognitive deficits, which was associated with brain oxidative stress and apoptosis. Resveratrol (RSV) is an anti-apoptotic and anti-oxidative. This study aimed to investigate neuroprotective effects and involved molecular mechanisms in TBI.

MATERIAL AND METHODS: RSV and p38 inhibitor were administrated to TBI rats. Cognitive deficits were evaluated by Morris water maze assay. Reactive oxygen species (ROS) and apoptosis were detected in rat brains by fluorescent staining. Western blotting was used to assess the phosphorylation of p38 and the expression levels of Nrf2, HO1, and activated caspase-3.

RESULTS: RSV administration attenuated cognitive deficits of TBI rats. The ROS generation and apoptosis in the brain of TBI rats were suppressed by RSV treatment. Moreover, RSV treatment recovered activation of p38/Nrf2/HO1 signaling pathway. The co-administration of p38 inhibitor impaired RSV’s attenuating effects on cognitive deficits, brain apoptosis, and ROS generation.

CONCLUSIONS: RSV attenuated cognitive deficits of TBI by inhibiting oxidative stress-mediated apoptosis via targeting p38/Nrf2 signaling.

Keywords: Brain Injuries, Cognitive Dissonance, Oxidative Stress

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750