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28 August 2018 : Laboratory Research

Coronin 1c and F-actin Promote Metastasis of Breast Cancer

Jianqiang Shao1BCDE, Hui Zhang1CD, Zunyi Wang1ABCDEF*

DOI: 10.12659/MSM.908929

Med Sci Monit 2018; 24: LBR5980-5987

Abstract

BACKGROUND: We studies the expression of Coronin 1c and F-actin protein in breast cancer and explored their relationship with breast cancer metastasis.

MATERIAL AND METHODS: A total of 210 breast cancer tissues and adjacent normal tissues were collected from January 2013 to December 2014. The expressions of Coronin 1c and F-actin were detected by immunohistochemistry and Western blotting. We analyzed the relationship between Coronin 1c and F-actin and clinical data of breast cancer.

RESULTS: The expressions of Coronin 1c and F-actin in breast cancer tissues were positively correlated (r=0.926, P<0.05) and were significantly higher than those in normal tissues (P<0.05). The Coronin 1c and F-actin expressions were not correlated with age, tumor size, ER expression, or PR expression in breast cancer patients (P>0.05), but were significantly correlated with HER-2 expression, histological grade, lymph node metastasis, molecular classification, and TNM (P<0.05). The expression of HER-2 in breast cancer tissues was positively correlated with the expression of Coronin 1c (r=0.706, P<0.05) and F-actin 1c, while F-actin protein in breast cancer tissues with lymph node metastasis was significantly higher than in those without lymph node metastasis (P<0.05).

CONCLUSIONS: Coronin 1c protein and F-actin protein are highly expressed in breast cancer and their expression may be related to the metastasis of breast cancer cells.

Keywords: Immunohistochemistry, Triple Negative Breast Neoplasms

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750