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Medical Science Monitor Basic Research


eISSN: 1643-3750

Differential and Predictive Value of Galectin-3 and Soluble Suppression of Tumorigenicity-2 (sST2) in Heart Failure with Preserved Ejection Fraction

Yameng Cui, Xin Qi, Anan Huang, Jiao Li, Wenguang Hou, Keqiang Liu

School of Graduate Studies, Tianjin University of Traditional Chinese Medicine, Tianjin, China (mainland)

Med Sci Monit 2018; 24: CLR5139-5146

DOI: 10.12659/MSM.908840

Available online: 2018-07-24

Published: 2018-07-24


BACKGROUND: Galectin-3 and soluble suppression of tumorigenicity-2 (sST2) are promising biomarkers of cardiac fibrosis and ventricular remodeling. The purpose of this study was to investigate the diagnostic and predictive value of galectin-3 and sST2 for use in patients who have heart failure with preserved ejection fraction (HFpEF).
MATERIAL AND METHODS: A total of 217 hospitalized patients with HF and 30 controls from a physical examination center were included. Venous blood was collected for the detection of circulating expression of galectin-3 and sST2. All the included patients were followed up regularly for 1 year (12±1 months).
RESULTS: The concentrations of galectin-3 and NT-proBNP were substantially higher following decreased ejection fraction (both P=0.000), except for sST2 (P=0.068 vs. control). In ROC analyses, galectin-3 and NT-proBNP distinguished HFpEF from controls with an area under the curve (AUC) of 0.819 (95% CI: 0.75-0.89, P=0.000) and 0.806 (95% CI: 0.66–0.82, P=0.000). In contrast, sST2 obtained a lower AUC of 0.584 (95% CI: 0.49–0.68, P=0.17) compared to galectni-3 and NT-proBNP. After adjustment for clinical factors and NT-proBNP, galectin-3 was strongly correlated with an increased risk of the endpoint events in HFpEF patients, and the hazard ratio per 1 SD increase of the galectin-3 level was 2.33 (95%CI: 1.72–2.94, P=0.009).
CONCLUSIONS: Galectin-3 is superior to sST2 in distinguishing HFpEF from controls and HFrEF.

Keywords: Biological Markers, Galectin 3, Heart Failure, N-Terminal Acetyltransferase B