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25 March 2018 : Clinical Research  

Correlation Between Pigment Epithelium-Derived Factor (PEDF) level and Degree of Coronary Angiography and Severity of Coronary Artery Disease in a Chinese Population

Man Li1ABCDEFG, Shuxia Wang1ABCDEFG, Yan Zhang1ABCDEFG, Shouyuan Ma1ABCDEFG, Ping Zhu1ABCDEFG*

DOI: 10.12659/MSM.908534

Med Sci Monit 2018; 24: CLR1751-1758

Abstract

BACKGROUND: The role of pigment epithelium-derived factor (PEDF) in protection of coronary artery disease (CAD) remains controversial. The aim of this study was to reassess the value of PEDF in predicting the severity and prognosis of newly diagnosed stable CAD in a Chinese population.

MATERIAL AND METHODS: Plasma PEDF levels were measured in 259 stable CAD patients undergoing coronary angiography and 116 age- and sex-matched healthy controls. The severity of coronary atherosclerosis was assessed using Gensini score.

RESULTS: PEDF levels were significantly lower in CAD patients than in healthy subjects (5.856±0.790 vs. 6.658±1.070 μg/ml, respectively, p<0.01). Stepwise regression analysis showed a negative correlation between PEDF levels and severity of CAD as quantified by Gensini score value (β=–0.626, p<0.01).

CONCLUSIONS: Our study showed that plasma PEDF levels were significantly lower in CAD patients than in controls, and the plasma PEDF levels may be used as a potential predicator for coronary severity.

Keywords: Angiography, Coronary Artery Disease, Plasma

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750