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Clinical Therapeutic Effect of Naloxone Combined with Hemodialysis on Acute Severe Alcoholism

Guixia Wang, Zhenhe Li, Min Li, Shanmei Liu, Timei Shan, Jiaqiang Liu, Yuliang Zhang

Department of Hemodialysis, Linyi City Yishui Central Hospital, Linyi, Shandong, China (mainland)

Med Sci Monit 2018; 24:5363-5367

DOI: 10.12659/MSM.908382

Available online:

Published: 2018-08-02

BACKGROUND: The aim of this research was to investigate the treatment effect of naloxone combined with hemodialysis on acute severe alcoholism.
MATERIAL AND METHODS: We included 36 patients treated with naloxone combined with hemodialysis in Group I and 34 patients treated with naloxone without hemodialysis in Group II. The Glasgow coma scale (GCS) score, the consciousness recovery time, alanine amino transferase (ALT) level, and complications were analyzed.
RESULTS: Mean GCS score in Group I was higher than that in Group II, with a significant difference (P<0.05). The consciousness recovery time in Groups I and II were 3.0±0.8 h and 6.9±2.1 h, respectively, with a significant difference (P<0.05). After naloxone treatment and hemodialysis, the ALT level in Group I was lower than that in Group II (P<0.05). Moreover, the incidence of hepatic and renal function damages in Group I was smaller than that in Group II (P<0.05). Only 1 patient in Group I developed pneumonia, which was fewer than that in Group II, with a significant difference (P<0.05).
CONCLUSIONS: Naloxone combined with hemodialysis effectively reduces the central inhibition of alcohol, shortens consciousness recovery time, improves respiratory and cardiovascular function, decreases hepatic and renal function damages, and reduces the incidence of complications.

Keywords: Acute Disease, Alcoholism, Glasgow Coma Scale, Hemodialysis Units, Hospital, Naloxone