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02 August 2018 : Clinical Research

Clinical Therapeutic Effect of Naloxone Combined with Hemodialysis on Acute Severe Alcoholism

Guixia Wang1ABDE, Zhenhe Li2ACEF*, Min Li2BCDF, Shanmei Liu1BCDF, Timei Shan2ABDE, Jiaqiang Liu1CDEF, Yuliang Zhang2ABDF

DOI: 10.12659/MSM.908382

Med Sci Monit 2018; 24: CLR5363-5367

Abstract

BACKGROUND: The aim of this research was to investigate the treatment effect of naloxone combined with hemodialysis on acute severe alcoholism.

MATERIAL AND METHODS: We included 36 patients treated with naloxone combined with hemodialysis in Group I and 34 patients treated with naloxone without hemodialysis in Group II. The Glasgow coma scale (GCS) score, the consciousness recovery time, alanine amino transferase (ALT) level, and complications were analyzed.

RESULTS: Mean GCS score in Group I was higher than that in Group II, with a significant difference (P<0.05). The consciousness recovery time in Groups I and II were 3.0±0.8 h and 6.9±2.1 h, respectively, with a significant difference (P<0.05). After naloxone treatment and hemodialysis, the ALT level in Group I was lower than that in Group II (P<0.05). Moreover, the incidence of hepatic and renal function damages in Group I was smaller than that in Group II (P<0.05). Only 1 patient in Group I developed pneumonia, which was fewer than that in Group II, with a significant difference (P<0.05).

CONCLUSIONS: Naloxone combined with hemodialysis effectively reduces the central inhibition of alcohol, shortens consciousness recovery time, improves respiratory and cardiovascular function, decreases hepatic and renal function damages, and reduces the incidence of complications.

Keywords: Acute Disease, Alcoholism, Glasgow Coma Scale, Hemodialysis Units, Hospital, Naloxone

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750