Astragalus Polysaccharide Protects Neurons and Stabilizes Mitochondrial in a Mouse Model of Parkinson Disease
Hong Liu, Si Chen, Cunju Guo, Wenqiang Tang, Wei Liu, Yiming Liu
(Department of Neurology, Qilu Hospital of Shandong University, Jinan, Shandong, China (mainland))
Med Sci Monit 2018; 24:5192-5199
Astragalus polysaccharides (APS) have a very good therapeutic effect in the treatment of neurodegenerative diseases and nerve injury disease. However, research on Parkinson disease (PD) treatment with APS is lacking.
MATERIAL AND METHODS: The present study was designed to explore the effects of APS on the protection of neurons and mitochondrial in a mouse model of PD using behavioral experiments, and observations of mitochondrial structure and transmembrane potential.
RESULTS: It was shown that APS could attenuate 1-methyl-4-pheyl-1,2,3,6-tetrahydropyridine (MPTP)-induced motor dysfunction (P<0.01), increase the proportion of TH-positive cells (P<0.01), reverse MPTP-induced mitochondrial structural damage, and reduce MPTP-induced high levels of reactive oxygen species (ROS) and increase MPTP-induced decrease in mitochondrial membrane potential. In addition, APS also decreased the bax/bcl2 ratio, and cytochrome-c and caspase-3 protein content (P<0.01) in substantia nigra in our mouse PD model.
CONCLUSIONS: APS provided a protective effect on neurons and mitochondrial in a mouse PD model.
Keywords: Mitochondrial Diseases, Parkinson Disease, Polysaccharides