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03 May 2018 : Clinical Research  

Predictive Factors of Skip Metastasis in Papillary Thyroid Cancer

Wen-Xu Jin1BC, Yi-Xiang Jin2BE, Dan-Rong Ye2BD, Zhou-Ci Zheng2BF, Yi-Han Sun2B, Xiao-Fen Zhou2B, Quan Li2BG, Ou-Chen Wang2AG*, Hai-Guang Liu1E, Xiao-Hua Zhang2AG

DOI: 10.12659/MSM.907357

Med Sci Monit 2018; 24: CLR2744-2749

Abstract

BACKGROUND: Skip metastasis is defined as metastasis incident to the lateral compartment without involvement of the central compartment, and is generally unpredictable in papillary thyroid cancer (PTC). The present study aimed to investigate the frequency and predictor value of skip metastasis in PTC patients.

MATERIAL AND METHODS: A total of 355 patients diagnosed with thyroid cancer who had received a prior complete thyroidectomy with bilateral central neck and ipsilateral lateral neck lymph node dissection were enrolled in this study. The clinicopathological and ultrasound features were analyzed. A univariate and multivariate analysis were performed to identify the risk factors of skip metastasis.

RESULTS: The frequency of skip metastasis was 12.4% (44/355). The PTC patients with skip metastasis exhibited fewer lymph node metastasis, which was more commonly detected in tumor size ≤1 cm (OR 9.354; p=0.001; 95% confidence interval (CI) 1.865–26.735), tumors located in upper pole (OR 3.822; p<0.001; 95% CI 1.935–7.549), without a well-defined margin (OR 2.528; p=0.016; CI 1.191–5.367), and extrathyroidal extension (OR 2.406; p=0.013; CI 1.691–4.367).

CONCLUSIONS: Skip metastasis was common in PTC. The PTC patients with a tumor size ≤1.0 cm, located in the upper pole, without a well-defined margin and extrathyroidal extension should be carefully evaluated for skip metastasis.

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750