20 October 2018 : Clinical Research
Body Adiposity Changes After Lifestyle Interventions in Children/Adolescents and the NYD-SP18 and TMEM18 VariantsLukas Zlatohlavek1ABDF, Vit Maratka2ABE, Eva Tumova1ABD, Richard Ceska1ADE, Vera Lanska3CDE, Michal Vrablik1ACDEF, Jaroslav A. Hubacek3ACDEFG*
Med Sci Monit 2018; 24: CLR7493-7498
BACKGROUND: This study was carried out to determine the relationship between the common TMEM-18 (rs4854344, G>T) and NYD-SP18 (rs6971091, G>A) gene variants and weight loss after lifestyle interventions (increased physical activity in conjunction with optimal dietary intake) in overweight/obese children/adolescents.
MATERIAL AND METHODS: We genotyped 684 unrelated, white, non-diabetic children (age 12.7±2.1 years, average BMI at baseline 30.66±4.80 kg/m²). Anthropometric and biochemical examinations were performed before and after 4 weeks of an intensive lifestyle intervention.
RESULTS: The mean weight loss achieved was 5.20±2.02 kg (P<0.001). NYDSP-18 AA homozygotes had significantly higher abdominal skinfold value before and after the intervention (both, P=0.001). No significant associations between BMI decrease and the NYD-SP18 and TMEM18 variants were found. Associations between all anthropometrical and biochemical changes and genes remained non-significant after data were adjusted for sex, age, and baseline values.
CONCLUSIONS: Decreased body weight in overweight/obese children is not significantly influenced by the NYD-SP18 rs6971091 or TMEM18 rs4854344 polymorphisms.
Keywords: Child, Intervention Studies, Obesity, Polymorphism, Single Nucleotide
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