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Low Expression and Clinical Value of hsa_circ_0049224 and has_circ_0049220 in Systemic Lupus Erythematous Patients

Chengzhong Zhang, Jie Huang, Yue Chen, Weimin Shi

Department of Dermatology, Shanghai General Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China (mainland)

Med Sci Monit 2018; 24:1930-1935

DOI: 10.12659/MSM.906507

Available online:

Published: 2018-04-02

BACKGROUND: The aim of this study was to discuss the possible roles and clinical value of 2 circRNAs (hsa_circ_0049224 and has_circ_0049220) in SLE patients.
MATERIAL AND METHODS: Reverse-transcription real-time polymerase chain reaction (RT-PCR) was conducted to detect the expressions of hsa_circ_0049224, has_circ_0049220, and DNMT1 in peripheral blood mononuclear cells (PBMCs) from 18 diagnosed SLE patients and 10 healthy controls.
RESULTS: We found that the expressions of hsa_circ_0049224 and has_circ_0049220 in healthy control groups were both much higher than those in inactive and active SLE patients. The expression level of DNMT1 is positively correlated with the expressions of hsa_circ_0049224 and has_circ_0049220. Moreover, there was a negative correlation between the SLE Disease Activity Index (SLEDAI) and the expressions of hsa_circ_0049224 and has_circ_0049220. We also found that these 2 circRNAs are associated with some clinical characteristics of SLE.
CONCLUSIONS: Hsa_circ_0049224 and has_circ_0049220 are probable factors involved in the pathogenesis of SLE, and they have potential clinical value in SLE.

Keywords: Biological Markers, Systemic Lupus Erythematous, clinical