09 August 2017 : Animal Research
Med Sci Monit 2017; 23:3844-3853
BACKGROUND: Cinnamaldehyde has anti-diabetic effects such as blood glucose and lipid regulation, insulin resistance improvement, and antioxidation. However, there have been few related reports published on the effect of cinnamaldehyde in the treatment of diabetic vascular endothelial dysfunction and prevention of diabetic vascular complications. We aimed to explore the effect and mechanism of cinnamaldehyde on glucose metabolism and vessel function in db/db mice.
MATERIAL AND METHODS: General condition of mice (n=10 for each group) such as food intake, fasting blood glucose, body weight, and insulin sensitivity was monitored periodically during the intervention time for 12 weeks. Immunofluorescent staining and hematoxylin and eosin staining of the pancreas were employed to observe the effects of cinnamaldehyde on the function and morphology of pancreatic islets. Acetylcholine (Ach) solution was used to observe Ach-induced endothelium-dependent vasodilatation and nitroglycerin (NTG) solution was used to observe NTG-induced endothelium-independent vasodilatation.
RESULTS: There was significant improvement in general condition of db/db mice, including food intake, fasting blood glucose, body weight, and insulin sensitivity. After cinnamaldehyde intervention, the function and morphology of pancreatic islets was significantly improved in db/db mice compared to the control group. The level of superoxide anion significantly decreased while the level of nitric oxide significantly increased in db/db mice. Cinnamaldehyde had significant effects on endothelium-dependent diastolic function and vascular remodeling.
CONCLUSIONS: Cinnamaldehyde can significantly reduce fasting glucose levels, increase insulin sensitivity, and improve islet morphology and function in db/db mice. Experiments showed that cinnamaldehyde could effectively improve vascular endothelium-dependent diastolic function with antihypertensive trend, which provides experimental evidence for further cinnamaldehyde clinical use.
Keywords: Insulin Resistance, Superoxides
01 January 2022 : EditorialEditorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Patients
Med Sci Monit 2022; 28:e935952
11 January 2022 : Clinical ResearchA Remote Questionnaire-Based Study to Compare Alcohol Use in 1030 Final-Year High School Students in Split-...
Med Sci Monit In Press; DOI: 10.12659/MSM.935567
08 November 2021 : Database AnalysisVirtual Screening and Molecular Docking to Study the Mechanism of Chinese Medicines in the Treatment of Cor...
Med Sci Monit In Press; DOI: 10.12659/MSM.934102
31 December 2021 : Clinical ResearchA Prospective Observational Study of 42 Patients with COVID-19 infection and a History of Hepatitis C Virus...
Med Sci Monit 2021; 27:e935075
19 Jan 2022 : Clinical ResearchA Retrospective Study to Compare the Effects of Methylprednisolone and Dexamethasone in 35 Patients with An...
Med Sci Monit In Press; DOI: 10.12659/MSM.934703
17 Jan 2022 : Clinical ResearchUnveiling the Differences in Biological Properties of Dental Pulp Stem Cells from Normal and Inflamed Pulp:...
Med Sci Monit In Press; DOI: 10.12659/MSM.934511
14 Jan 2022 : Database AnalysisIdentification of Key Genes Associated with Brain Metastasis from Breast Cancer: A Bioinformatics Analysis
Med Sci Monit In Press; DOI: 10.12659/MSM.935071
Most Viewed Current Articles
30 Dec 2021 : Clinical ResearchRetrospective Study of Outcomes and Hospitalization Rates of Patients in Italy with a Confirmed Diagnosis o...
Med Sci Monit 2021; 27:e935379
01 Nov 2020 : Review articleLong-Term Respiratory and Neurological Sequelae of COVID-19
Med Sci Monit 2020; 26:e928996
05 Mar 2020 : Clinical ResearchThe Effects of Social Support on Sleep Quality of Medical Staff Treating Patients with Coronavirus Disease ...
Med Sci Monit 2020; 26:e923549