12 February 2018 : Laboratory Research
Helical Flow Component of Left Ventricular Assist Devices (LVADs) Outflow Improves Aortic Hemodynamic States
Qi Zhang1BDE, Bin Gao1ABDEFG*, Yu Chang1FGDOI: 10.12659/MSM.905940
Med Sci Monit 2018; 24: LBR869-879
Abstract
BACKGROUND: Although LVADs are confirmed to have strong effects on aortic hemodynamics, the precise mechanisms of the helical flow component of LVAD outflow are still unclear.
MATERIAL AND METHODS: To clarify these effects, 3 cases – normal case, flat flow case, and realistic flow case – were designed and studied by using the CFD approach. The normal case denoted the normal aorta without LVAD support, and the flat flow case represented the aorta with the outflow cannula. Similarly, the realistic flow case included the aortic model, the model of outflow cannula, and the model of LVAD. The velocity vector, blood streamline, distribution of wall shear stress (WSS), and the local normalized helicity (LNH) were calculated.
RESULTS: The results showed that the helical component of LVAD outflow significantly improved the aortic hemodynamics. Compared with the flat flow case, the helical flow eliminated the vortex near the outer wall of the aorta and improved the blood flow transport (normal case 0.1 m/s vs. flat flow case 0.14 m/s vs. realistic flow case 0.30 m/s) at the descending aorta. Moreover, the helical flow was confirmed to even the distribution of WSS, reduce the peak value of WSS (normal case 0.92 Pa vs. flat flow case 7.39 Pa vs. realistic flow case 5.2Pa), and maintain a more orderly WSS direction.
CONCLUSIONS: The helical flow component of LVAD outflow has significant advantages for improving aortic hemodynamic stability. Our study provides novel insights into LVAD optimization.
Keywords: Finite Element Analysis, Heart, Artificial, Hemodynamics
Editorial
01 April 2024 : Editorial
Editorial: Forty Years of Waiting for Prevention and Cure of HIV Infection – Ongoing Challenges and Hopes for Vaccine Development and Overcoming Antiretroviral Drug ResistanceDOI: 10.12659/MSM.944600
Med Sci Monit 2024; 30:e944600
In Press
06 Mar 2024 : Clinical Research
Comparison of Outcomes between Single-Level and Double-Level Corpectomy in Thoracolumbar Reconstruction: A ...Med Sci Monit In Press; DOI: 10.12659/MSM.943797
21 Mar 2024 : Meta-Analysis
Economic Evaluation of COVID-19 Screening Tests and Surveillance Strategies in Low-Income, Middle-Income, a...Med Sci Monit In Press; DOI: 10.12659/MSM.943863
10 Apr 2024 : Clinical Research
Predicting Acute Cardiovascular Complications in COVID-19: Insights from a Specialized Cardiac Referral Dep...Med Sci Monit In Press; DOI: 10.12659/MSM.942612
06 Mar 2024 : Clinical Research
Enhanced Surgical Outcomes of Popliteal Cyst Excision: A Retrospective Study Comparing Arthroscopic Debride...Med Sci Monit In Press; DOI: 10.12659/MSM.941102
Most Viewed Current Articles
17 Jan 2024 : Review article
Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron VariantDOI :10.12659/MSM.942799
Med Sci Monit 2024; 30:e942799
14 Dec 2022 : Clinical Research
Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase LevelsDOI :10.12659/MSM.937990
Med Sci Monit 2022; 28:e937990
16 May 2023 : Clinical Research
Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...DOI :10.12659/MSM.940387
Med Sci Monit 2023; 29:e940387
01 Jan 2022 : Editorial
Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...DOI :10.12659/MSM.935952
Med Sci Monit 2022; 28:e935952