30 June 2017 : Laboratory Research
Transcription Factor 21 (TCF21) rs12190287 Polymorphism is Associated with Osteosarcoma Risk and Outcomes in East Chinese Population
Zhenghui Jiang1ABCE*, Weikang Zhang1CD, Zhikang Chen2EF, Jinxiang Shao1BD, Liqiu Chen1CDE, Zhaohui Wang3EGDOI: 10.12659/MSM.905595
Med Sci Monit 2017; 23:3185-3191
Abstract
BACKGROUND: The transcription factor 21 (TCF21) gene is believed to be a tumor suppressor gene. TCF21 gene polymorphisms were found to play a role in the tumorigenesis of some solid malignancies. We raised a hypothesis that genetic polymorphisms of TCF21 were correlated with risk and prognosis of osteosarcoma.
MATERIAL AND METHODS: We recruited 225 young osteosarcoma individuals and 250 cancer-free controls. Five tagging SNPs (TCF21 rs2327429 T>C, rs2327433 A>G, rs2327433 A>G, rs12190287 C>G, and rs4896011 T>A) were genotyped. Preserved DNA samples from blood underwent PCR analysis for genotyping.
RESULTS: rs12190287 C>G is a good predictor of osteosarcoma risk and outcomes. The CG and GG genotypes of rs12190287 predict elevated risk of osteosarcoma. Besides, rs12190287 CG and GG genotypes are associated with Enneking stage and potential in forming metastasis of osteosarcoma.
CONCLUSIONS: Genetic polymorphisms of TCF21 are potentially predictive for osteosarcoma risk and outcomes.
Keywords: Polymorphism, Single Nucleotide, Prognosis
Weekly Editorial
18 October 2021 : Editorial
Editorial: Global Initiatives Support the Use and Regulation of Digital Health Technology During the COVID-19 PandemicDOI: 10.12659/MSM.935123
Med Sci Monit 2021; 27:e935123
SARS-CoV-2/COVID-19
20 October 2021 : Editorial
Editorial: The 2021 European Society of Cardiology (ESC) Guidelines on the Real-World Prevention of Atheros...Med Sci Monit In Press; DOI: 10.12659/MSM.935172
11 October 2021 : Clinical Research
Clinical Features and Temporal Lung Radiographic Changes in 25 Patients Recovering from COVID-19 Pneumonia:...Med Sci Monit In Press; DOI: 10.12659/MSM.933381
08 September 2021 : Clinical Research
Acceptance of COVID-19 Vaccination and Its Associated Factors Among Cancer Patients Attending the Oncology ...Med Sci Monit In Press; DOI: 10.12659/MSM.932788
18 October 2021 : Editorial
Editorial: Global Initiatives Support the Use and Regulation of Digital Health Technology During the COVID-...Med Sci Monit 2021; 27:e935123
In Press
20 Oct 2021 : Editorial
Editorial: The 2021 European Society of Cardiology (ESC) Guidelines on the Real-World Prevention of Atheros...Med Sci Monit In Press; DOI: 10.12659/MSM.935172
19 Oct 2021 : Review article
Role of NLRP3 Inflammasome in Myocardial Ischemia-Reperfusion Injury and Ventricular RemodelingMed Sci Monit In Press; DOI: 10.12659/MSM.934255
18 Oct 2021 : Clinical Research
Adverse Side Effects Associated with Corticosteroid Therapy: A Study in 39 Patients with Generalized Myasth...Med Sci Monit In Press; DOI: 10.12659/MSM.933296
13 Oct 2021 : Clinical Research
Endovascular Repair of Thoracic Aorta Injury: 17 Years of Single-Center ExperienceMed Sci Monit In Press; DOI: 10.12659/MSM.934479
Most Viewed Current Articles
20 Mar 2020 : Clinical Research
Social Capital and Sleep Quality in Individuals Who Self-Isolated for 14 Days During the Coronavirus Diseas...DOI :10.12659/MSM.923921
Med Sci Monit 2020; 26:e923921
15 Apr 2020 : Clinical Research
Psychological Impact and Coping Strategies of Frontline Medical Staff in Hunan Between January and March 20...DOI :10.12659/MSM.924171
Med Sci Monit 2020; 26:e924171
05 May 2020 : Review article
An Evidence Based Perspective on mRNA-SARS-CoV-2 Vaccine DevelopmentDOI :10.12659/MSM.924700
Med Sci Monit 2020; 26:e924700
26 Apr 2020 : Clinical Research
Comparison of Prevalence and Associated Factors of Anxiety and Depression Among People Affected by versus P...DOI :10.12659/MSM.924609
Med Sci Monit 2020; 26:e924609