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19 January 2018 : Clinical Research

Association Study of Polymorphisms in Genes Relevant to Vitamin B12 and Folate Metabolism with Childhood Autism Spectrum Disorder in a Han Chinese Population

Zengyu Zhang1ABCDEFG, Lianfang Yu1ABDEF, Sufang Li1ACDEF, Jun Liu2ABCDEF*

DOI: 10.12659/MSM.905567

Med Sci Monit 2018; 24: CLR370-376

Abstract

BACKGROUND: Both genetic and environmental factors play a role in the development of autism spectrum disorder (ASD). This case-control study examined the association between childhood ASD and single-nucleotide polymorphisms (SNPs) in genes involved with vitamin B12 and folate metabolism.

MATERIAL AND METHODS: Genotypes of transcobalamin 2 (TCN2) rs1801198, methionine synthase (MTR) rs1805087, methionine synthase reductase (MTRR) rs1801394, and methylene tetrahydrofolate reductase (MTHFR) rs1801133 were examined in 201 children with ASD and 200 healthy controls from the Han Chinese population.

RESULTS: Our results showed no association of all examined SNPs with childhood ASD and its severity.

CONCLUSIONS: None of the examined SNPs were a risk factor for the susceptibility to childhood ASD and severity of the disease in a Han Chinese population.

Keywords: Autistic Disorder, Child Development Disorders, Pervasive, Polymorphism, Single Nucleotide

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750