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13 June 2018 : Clinical Research  

Changes in Gray Matter Density, Regional Homogeneity, and Functional Connectivity in Methamphetamine-Associated Psychosis: A Resting-State Functional Magnetic Resonance Imaging (fMRI) Study

Shengyu Zhang1ABE, Qiang Hu2ABE, Tao Tang1C, Chao Liu1DF, Chengchong Li3B, Yin-Yin Zang4D, Wei-Xiong Cai1D*

DOI: 10.12659/MSM.905354

Med Sci Monit 2018; 24: CLR4020-4030

Abstract

BACKGROUND: Using regional homogeneity (ReHo) blood oxygen level-dependent functional MR (BOLD-fMRI), we investigated the structural and functional alterations of brain regions among patients with methamphetamine-associated psychosis (MAP).

MATERIAL AND METHODS: This retrospective study included 17 MAP patients, 16 schizophrenia (SCZ) patients, and 18 healthy controls. Informed consent was obtained from all patients before the clinical assessment, the severity of clinical symptoms was evaluated prior to the fMRI scanning, and then images were acquired and preprocessed after each participant received 6-min fRMI scanning. The participants all underwent BOLD-fMRI scanning. Voxel-based morphometry was used to measure gray matter density (GMD). Resting-state fMRI (rs-fMRI) was conducted to analyze functional MR, ReHo, and functional connectivity (FC).

RESULTS: GMD analysis results suggest that MAP patients, SCZ patients, and healthy volunteers show different GMDs within different brain regions. Similarly, the ReHo analysis results suggest that MAP patients, SCZ patients, and healthy volunteers have different GMDs within different brain regions. Negative correlations were found between ReHo- and the PANSS-positive scores within the left orbital interior frontal gyrus (L-orb-IFG) of MAP patients. ReHo- and PANSS-negative scores of R-SFG were negatively correlated among SCZ patients. The abnormal FC of R-MFG showed a negative correlation with the PANSS score among MAP patients.

CONCLUSIONS: The abnormalities in brain structure and FC were associated with the development of MAP.

Keywords: Brain Diseases, Methamphetamine, Psychotic Disorders

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750