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27 November 2017 : Laboratory Research  

Protective Role of TNIP2 in Myocardial Injury Induced by Acute Pancreatitis and Its Mechanism

Hualei Xie1ABCDEFG, Maoyong Yang1BDEF, Bo Zhang1BCDE, Min Liu1CDEF, Shumei Han1ABCDEFG*

DOI: 10.12659/MSM.904398

Med Sci Monit 2017; 23:5650-5656

Abstract

BACKGROUND: Aberrant regulation of nuclear factor-κB (NF-κB) and the signaling pathways that regulate its activity have been found to be involved in various pathologies, particularly cancers, as well as inflammatory and autoimmune diseases. Acute pancreatitis (AP) is a complex pathological process, depending on autodigestion caused by premature activation of zymogens. This study aimed to investigate the effect of high expression of TNIP2 gene on AP and AP-induced myocardial injury.

MATERIAL AND METHODS: To investigate the effect of TNIP2 on AP and AP-induced myocardial injury, we established an AP cell model and rat model. HE staining was applied for histological examination. ELISA was used to determine the level of pro-inflammatory cytokines (TNF-α and IL-6) and myocardial injury markers (LDH and CK-MB). QRT-PCR and Western blot analysis were performed to determine the mRNA and protein level of related genes, respectively.

RESULTS: We found that the protein level of TNIP2 was relatively higher in the normal AR42J cells. At 4 h after stimulating with cerulein, the protein level of TNIP2 decreased, reached a minimum at 8 h, and then gradually increased. We also found that TNIP2 was correlated with the activation of NF-κB in cerulein-stimulated AR42J cells, and TNIP2 over-expression inhibited the inflammatory response caused by cerulein. Moreover, our results suggest that TNIP2 over-expression relieved the cerulein-triggered inflammatory response and AP-induced myocardial injury in mice.

CONCLUSIONS: TNIP2 was shown to exert a protective effect on AP and AP-induced myocardial injury.

Keywords: Heart Injuries, NF-kappa B

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750