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High Expression of Angiogenic Factor with G-Patch and FHA Domain1 (AGGF1) Predicts Poor Prognosis in Gastric Cancer

Han-Hui Yao, Ben-Jun Wang, Yang Wu, Qiang Huang

(Department of General Surgery, Anhui Provincial Hospital, Anhui Medical University, Hefei, Anhui, China (mainland))

Med Sci Monit 2017; 23:1286-1294

DOI: 10.12659/MSM.903248

Published: 2017-03-14

BACKGROUND: Angiogenic factor with G-patch and FHA domain1 (AGGF1 or VG5Q) is a newly identified human angiogenic factor. The aim of this study was to explore AGGF1 expression level in gastric cancer and detect its correlation with the prognosis.
MATERIAL AND METHODS: Immunohistochemistry was performed to detect AGGF1 level in gastric cancer and its adjacent noncancerous samples of 198 cases, and the relationships among the expression levels of AGGF1, vascular endothelial growth factor (VEGF), and prognosis were analyzed.
RESULTS: Expression of AGGF1 in gastric cancer samples was significantly higher than that in adjacent noncancerous samples (P<0.001). The overall survival rate (OS) of patients with high AGGF1 expression was significantly lower than that of patients with low AGGF1 expression (P=0.000). The Cox model analysis demonstrated that expression of AGGF1 was an independent biomarker for prediction of patients’ survival in gastric cancer.
CONCLUSIONS: High expression of AGGF1 predicts poor prognosis in gastric cancer patients. AGGF1 can be used as an independent factor to predict postoperative survival of patients with gastric cancer.

Keywords: Angiogenesis Inducing Agents, Stomach Neoplasms, Vascular Endothelial Growth Factor A