Logo Medical Science Monitor

Call: +1.631.470.9640
Mon - Fri 10:00 am - 02:00 pm EST

Contact Us

Logo Medical Science Monitor Logo Medical Science Monitor Logo Medical Science Monitor

08 August 2017 : Clinical Research  

Differentiation Diagnosis of Hypo-Intense T2 Area in Unilateral Peripheral Zone of Prostate Using Magnetic Resonance Spectroscopy (MRS): Prostate Carcinoma versus Prostatitis

Tong-hua ZhangABCDEF, Chun-hong HuAD, Jian-xin ChenB, Zheng-dao XuB, Jun-kang ShenG

DOI: 10.12659/MSM.903123

Med Sci Monit 2017; 23:3837-3843

Abstract

BACKGROUND: To determine whether magnetic resonance spectroscopy (MRS) can be used as a reliable denominator for the differentiation of prostatitis and prostate cancer (PCa) in the peripheral zone.

MATERIAL AND METHODS: Forty-three patients with unilateral peripheral zone PCa and 35 patients with unilateral peripheral zone prostatitis were recruited for this study. Magnetic resonance imaging (MRI) and MRS were acquired on a 1.5T MR scanner. The ratios of (Cho+Cr)/Cit of hypo-intense T2 area were calculated. The mean ratios of (Cho+Cr)/Cit in hypo-intense T2 area of PCa and that of prostatitis were compared retrospectively by t-test. The citrate and choline amplitudes in the hypo-intense T2 area were compared with that in the contralateral normal peripheral zone tissue.

RESULTS: The mean ratios of (Cho+Cr)/Cit in the hypo-intense T2 area of PCa was 3.0±2.48, whereas that of prostatitis was 5.2±7.08, without significant statistical difference (p=0.306). A reduction in citrate was seen in both PCa and prostatitis tissue, however, choline was elevated in PCa tissue, whereas on the contrary, choline had no significant change in cases of prostatitis.

CONCLUSIONS: The mean ratios of (Cho+Cr)/Cit had no specificity in differentiation of PCa and prostatitis in the peripheral zone, however, the metabolic pattern showed promise as an adjunct to conventional imaging in differentiating prostatitis from PCa in the peripheral zone.

Keywords: Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy, Prostatic Neoplasms, Prostatitis

Add Comment 0 Comments

Editorial

01 March 2024 : Editorial  

Editorial: First Regulatory Approvals for CRISPR-Cas9 Therapeutic Gene Editing for Sickle Cell Disease and Transfusion-Dependent β-Thalassemia

Dinah V. Parums

DOI: 10.12659/MSM.944204

Med Sci Monit 2024; 30:e944204

0:00

In Press

18 Mar 2024 : Clinical Research  

Sexual Dysfunction in Women After Tibial Fracture: A Retrospective Comparative Study

Med Sci Monit In Press; DOI: 10.12659/MSM.944136  

0:00

21 Feb 2024 : Clinical Research  

Potential Value of HSP90α in Prognosis of Triple-Negative Breast Cancer

Med Sci Monit In Press; DOI: 10.12659/MSM.943049  

22 Feb 2024 : Review article  

Differentiation of Native Vertebral Osteomyelitis: A Comprehensive Review of Imaging Techniques and Future ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943168  

23 Feb 2024 : Clinical Research  

A Study of 60 Patients with Low Back Pain to Compare Outcomes Following Magnetotherapy, Ultrasound, Laser, ...

Med Sci Monit In Press; DOI: 10.12659/MSM.943732  

Most Viewed Current Articles

16 May 2023 : Clinical Research  

Electrophysiological Testing for an Auditory Processing Disorder and Reading Performance in 54 School Stude...

DOI :10.12659/MSM.940387

Med Sci Monit 2023; 29:e940387

0:00

17 Jan 2024 : Review article  

Vaccination Guidelines for Pregnant Women: Addressing COVID-19 and the Omicron Variant

DOI :10.12659/MSM.942799

Med Sci Monit 2024; 30:e942799

0:00

14 Dec 2022 : Clinical Research  

Prevalence and Variability of Allergen-Specific Immunoglobulin E in Patients with Elevated Tryptase Levels

DOI :10.12659/MSM.937990

Med Sci Monit 2022; 28:e937990

0:00

01 Jan 2022 : Editorial  

Editorial: Current Status of Oral Antiviral Drug Treatments for SARS-CoV-2 Infection in Non-Hospitalized Pa...

DOI :10.12659/MSM.935952

Med Sci Monit 2022; 28:e935952

0:00

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750