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Medical Science Monitor Basic Research


eISSN: 1643-3750

In-Depth Analysis on Influencing Factors of Adjacent Segment Degeneration After Cervical Fusion

Chaojie Yu, Xiaoping Mu, Jianxun Wei, Ye Chu, Bin Liang

Department of Orthopaedics, The People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi, China (mainland)

Med Sci Monit 2016; 22:4902-4910

DOI: 10.12659/MSM.902179

Available online: 2016-12-14

Published: 2016-12-14


BACKGROUND: To explore the related influencing factors of adjacent segment degeneration (ASD) after cervical discectomy and fusion (ACDF).
MATERIAL AND METHODS: A retrospective analysis of 263 patients who underwent ACDF was carried out. Cervical x-ray and magnetic resonance imaging (MRI) were required before operation, after operation, and at the last follow-up. General information and some radiographic parameters of all patients were measured and recorded. According to the imaging data, patients were put into one of two groups: non-ASD group and ASD group. The differences between the two groups were compared by t-test and χ²-test, and the related influencing factors of ASD were analyzed by logistic regression.
RESULTS: In all, 138 patients had imaging ASD. Comparing the age, the postoperative cervical arc chord distance (po-CACD), and the plate to disc distance (PDD) of the two groups, differences were statistically significant (p<0.05). The gender, the fusion segment number, the pre-CACD, the pre-and-po CACD, the preoperative cervical spinal canal ratio, and the upper and lower disc height (DH) showed no statistical difference between the two groups (p>0.05). The results of logistic regression analysis showed that there were significant correlations in the following characteristics: age, postoperative po-CACD, and the PDD (p<0.05). Of all these characteristics, the correlation of age was the highest (R=1.820).
CONCLUSIONS: Age, po-CACD, and PDD were risk factors for ASD after ACDF. The older the operation age, the worse the recovery was of postoperative physiological curvature of cervical spine, and a PDD < 5 mm was more likely to lead to ASD.

Keywords: intervertebral disc degeneration, Spinal Fusion, Uterine Cervical Diseases