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22 December 2016 : Review article

Multiple Roles of WNT5A in Breast Cancer

Ruolan Zeng1BCEF, Junhui Huang1A*, Mei-zuo Zhong1AD, Li Li1D, Guorong Yang2B, Li Liu3F, Yin Wu4CF, Xiaoyi Yao1B, Jing Shi5B, Zhifu Wu1B

DOI: 10.12659/MSM.902022

Med Sci Monit 2016; 22:5058-5067

Abstract

ABSTRACT: Breast cancer is one of the most common malignant tumors of women. Modern combinatorial therapeutic regimens can reduce patient tumor burdens to undetectable levels, yet in many cases these tumors will relapse. Understanding of breast cancer biology, developing more potent therapeutic approaches, and overcoming resistance are of great importance. WNT5A is a non-canonical signaling member of the WNT family. Its role in breast cancer still remains unclear. Most of the evidence shows that WNT5A is a suppressor in breast cancer and loss of its expression is associated with poor prognosis, while some evidence suggests the tumorigenicity of WNT5A. WNT signaling molecules are potent targets for treatment of cancer. Therefore, understanding the role of WNT5A in breast cancer may provide new ideas and methods for breast cancer treatment. We review the evidence concerning WNT5A and breast cancer involving the signaling pathways and the molecular-targeted therapy of WNT5A. Our results show that the role WNT5A plays depends on the availability of key receptors and intercellular interactions among different cell types.

Keywords: Molecular Targeted Therapy, Wnt Signaling Pathway

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750