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eISSN: 1643-3750

Serum Liver Fibrosis Markers in the Prognosis of Liver Cirrhosis: A Prospective Observational Study

Xingshun Qi, Xu Liu, Yongguo Zhang, Yue Hou, Linan Ren, Chunyan Wu, Jiang Chen, Chunlian Xia, Jiajun Zhao, Di Wang, Yanlin Zhang, Xia Zhang, Hao Lin, Hezhi Wang, Jinling Wang, Zhongmin Cui, Xueyan Li, Han Deng, Feifei Hou, Ying Peng, Xueying Wang, Xiaodong Shao, Hongyu Li, Xiaozhong Guo

Liver Cirrhosis Group, Department of Gastroenterology, General Hospital of Shenyang Military Area, Shenyang, Liaoning, China (mainland)

Med Sci Monit 2016; 22:2720-2730

DOI: 10.12659/MSM.900441

ClinicalTrial.gov reg # NCT02335073

Available online:

Published: 2016-08-02


BACKGROUND: The prognostic role of serum liver fibrosis markers in cirrhotic patients remains unclear. We performed a prospective observational study to evaluate the effect of amino-terminal pro-peptide of type III pro-collagen (PIIINP), collagen IV (CIV), laminin (LN), and hyaluronic acid (HA) on the prognosis of liver cirrhosis.
MATERIAL AND METHODS: All patients who were diagnosed with liver cirrhosis and admitted to our department were prospectively enrolled. PIIINP, CIV, LN, and HA levels were tested.
RESULTS: Overall, 108 cirrhotic patients were included. Correlation analysis demonstrated that CIV (coefficient r: 0.658, p<0.001; coefficient r: 0.368, p<0.001), LN (coefficient r: 0.450, p<0.001; coefficient r: 0.343, p<0.001), and HA (coefficient r: 0.325, p=0.001; coefficient r: 0.282, p=0.004) levels, but not PIIINP level (coefficient r: 0.081, p=0.414; coefficient r: 0.090, p=0.363), significantly correlated with Child-Pugh and MELD scores. Logistic regression analysis demonstrated that HA (odds ratio=1.00003, 95% confidence interval [CI]=1.000004–1.000056, p=0.022) was significantly associated with the 6-month mortality. Receiver operating characteristics analysis demonstrated that the area under the curve (AUC) of HA for predicting the 6-month mortality was 0.612 (95%CI=0.508–0.709, p=0.1531).
CONCLUSIONS: CIV, LN, and HA levels were significantly associated with the severity of liver dysfunction, but might be inappropriate for the prognostic assessment of liver cirrhosis.

Keywords: Fibrosis, Liver Cirrhosis, Survival



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