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13 February 2017 : Review article

The Role of Uric Acid in Hypertension of Adolescents, Prehypertension and Salt Sensitivity of Blood Pressure

Yang Wang1AE, Jia-Wen Hu1AE, Yong-Bo Lv1EF, Chao Chu1E, Ke-Ke Wang1E, Wen-Ling Zheng1F, Yu-Meng Cao1E, Zu-Yi Yuan1E, Jian-Jun Mu1AG*

DOI: 10.12659/MSM.899563

Med Sci Monit 2017; 23:790-795

Abstract

ABSTRACT: Uric acid is the end product of purine metabolism. Metabolic disorders of uric acid are associated with many disease states. Substantial evidence suggests the possible role of uric acid as a mediator of high blood pressure. Elevated uric acid is closely associated with new onset essential hypertension in adolescents and prehypertension; and urate-lowering agents can significantly improve these early stages of hypertension. Uric acid also influences salt sensitivity of blood pressure through two phases. Local renin-angiotensin-aldosterone system activation initiates renal damage, arteriolopathy, and endothelium dysfunction, which is followed by the dysregulation of sodium homeostasis, thereby leading to increased salt sensitivity. In this review we summarize the available evidence to contribute to a better understanding of the casual relationship between uric acid and early or intermediate stages of hypertension. We hope our review can contribute to the prevention of hypertension or provide new insights into a treatment that would slow the progression of hypertension.

Keywords: Child, Hypertension, prehypertension, Uric Acid

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750