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15 January 2017 : Animal Research

Leptin Influences Healing in the Sprague Dawley Rat Fracture Model

Pengcheng Liu1ABCDEFG, Ming Cai1ABCDEFG*

DOI: 10.12659/MSM.899259

Med Sci Monit 2017; 23:258-265

Abstract

BACKGROUND: Leptin plays a crucial role in bone metabolism, and its level is related to bone callus formation in the fracture repair process. The objective of this study was to evaluate the effect of recombinant leptin on the healing process of femoral fractures in rats.

MATERIAL AND METHODS: Forty-eight male Sprague Dawley (SD) rats with an average body weight of 389 g (range: 376–398 g) and an average age of 10 weeks were included in this animal research, and all rats were randomly divided into two major groups. Then standardized femur fracture models were implemented in all SD rats. Rats in the control group were treated with only 0.5 mL of physiological saline, and rats in the experimental group were treated with recombinant leptin 5 μg/kg/d along with the same 0.5 mL of physiological saline for 42 days intraperitoneally. At the same time, each major group was evenly divided into three parallel subgroups for each parallel bone evaluation separately at the second, fourth, and sixth weeks. Each subgroup included eight rats.

RESULTS: The total radiological evaluation results showed that the healing progress of femoral fracture in the experimental group was superior to that in the control group from the fourth week. At the sixth week, experimental group rats began to present significantly better femoral fracture healing progress than that of the control group rats. Results of biomechanics show the ultimate load (N) and deflection ultimate load (mm) of the experimental group rats was significantly increased compared with that of the control group rats from the fourth week.

CONCLUSIONS: Our results suggest that leptin may have a positive effect on SD rat femur fracture healing.

Keywords: Femur, Fracture Healing, Leptin, Rats, Sprague-Dawley

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Medical Science Monitor eISSN: 1643-3750