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28 January 2017 : Clinical Research

Expression of Molecular Markers in Primary Sites and Metastatic Lymph Nodes of Lung Cancer Patients

Jie Li1DE, Wen Zhang2CE, Nannan Guo2A*, Jiangqi Yu2BDG, Yingnan Zhao2BDF, Shaojun Li2CFG

DOI: 10.12659/MSM.898688

Med Sci Monit 2017; 23:513-520

Abstract

BACKGROUND: Recently, there is an increasing interest in developing specific treatments while managing lung cancer cases. We tested the expressions of six molecular markers in the primary tumor and the metastatic lymph nodes of lung cancer patients at a single institution in China.

MATERIAL AND METHODS: A total of 48 patients with lung cancer who were admitted to the Department of Cardiothoracic Surgery, the First Affiliated Hospital of General Hospital of the Chinese People’s Liberation Army, from September 2010 to February 2011 were retrospectively reviewed.

RESULTS: One of the six biomarkers’ expressions, excision repair cross-complementation group 1 (ERCC-1), was found to be significantly different in primary tumors and metastatic sites in different cancer subtypes.

CONCLUSIONS: The onset and pathogenesis of small-cell lung carcinoma (SCLC) and non-small-cell lung carcinoma (NSCLC) are not completely understood, and the predictions of prognosis are not very reliable. The use of molecular markers to guide treatment of these cancers is currently in its initial stages.

Keywords: Biomarkers, Tumor - blood, Adult, China, DNA-Binding Proteins - metabolism, Endonucleases - metabolism, Lung Neoplasms - pathology, Lymph Nodes - pathology, Neoplasm Metastasis, Prognosis

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750