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eISSN: 1643-3750

Expression of IL-1α and IL-6 is Associated with Progression and Prognosis of Human Cervical Cancer

Zhiwang Song, Yun Lin, Xiaojuan Ye, Chan Feng, Yonglin Lu, Guang Yang, Chunyan Dong

Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland)

Med Sci Monit 2016; 22:4475-4481

DOI: 10.12659/MSM.898569

Available online:

Published: 2016-11-20


BACKGROUND: IL-1α and IL-6 are associated with the prognosis of a wide range of cancers, but their value in cervical cancer remains controversial. The aim of this study was to investigate the expression of IL-1α and IL-6 in cervical cancer and their significance in clinical prognosis.
MATERIAL AND METHODS: The expression of IL-1α and IL-6 in 105 formalin-fixed, paraffin-embedded cervical cancer tissues and adjacent non-tumor tissues was examined by immunohistochemistry. The results were semi-quantitatively scored and analyzed by chi-square test. Patient overall survival (OS) data was collected by follow-up and analyzed by Kaplan-Meier analysis.
RESULTS: The expression level of both IL-1α and IL-6 in cervical cancer tissue was higher than in adjacent non-tumor tissues (p<0.05). IL-1α expression was shown to be correlated with tumor size, FIGO histology grade, lymph node metastasis, stromal invasion, and tumor differentiation (p<0.05). IL-6 expression was shown to be correlated with tumor size, FIGO histology grade, and tumor differentiation (p<0.05). Patients with positive expression of IL-1α or IL-6 tended to have much shorter survival times than patients with negative expression. In addition, a multivariate Cox regression analysis demonstrated that IL-1α expression and lymph node metastasis were independent predictors of OS in cervical cancer patients.
CONCLUSIONS: The expression of IL-1α was significantly associated with tumor size, FIGO histology grade, lymph node metastasis, stromal invasion, and tumor differentiation. The expression of IL-6 was significantly associated with tumor size, FIGO histology grade, and tumor differentiation. Positive IL-1α and IL-6 expression was significantly correlated with poor prognosis. They may be considered valuable biomarkers for prognosis and potential therapeutic targets for cervical cancer.

Keywords: Biomarkers, Tumor - genetics, Adult, Disease Progression, Interleukin-1alpha - genetics, Interleukin-6 - genetics, Kaplan-Meier Estimate, Lymphatic Metastasis, Neoplasm Staging, Prognosis, Uterine Cervical Neoplasms - pathology



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