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eISSN: 1643-3750

Neutrophil/Lymphocyte Ratio, Serum Endocan, and Nesfatin-1 Levels in Patients with Psoriasis Vulgaris Undergoing Phototherapy Treatment

Aybala Erek Toprak, Emin Ozlu, Tugba Kevser Uzuncakmak, Emre Yalcınkaya, Sadık Sogut, Ayşe Serap Karadag

Department of Biochemistry, Istanbul Medeniyet University, School of Medicine, Istanbul, Turkey

Med Sci Monit 2016; 22:1232-1237

DOI: 10.12659/MSM.898240

Available online:

Published: 2016-04-12


#898240

BACKGROUND: Psoriasis is an autoimmune, inflammatory, and chronic disease. Recent studies have evaluated serum endocan and nesfatin-1 levels in patients with inflammatory disorders. The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker currently used in many diseases. The aim of the present study was to evaluate NLR, serum endocan, and nesfatin-1 levels in psoriasis vulgaris before and after narrow-band ultraviolet B (NB-UVB) phototherapy treatment and compared to healthy controls.
MATERIAL AND METHODS: This study was conducted on a total of 88 cases, 39 of which had psoriasis vulgaris and 49 were healthy volunteers. Thirty-nine psoriasis vulgaris patients underwent NB-UVB phototherapy treatment for 3 months. NLR, serum endocan, and nesfatin-1 levels were measured in all psoriasis patients before and after NB-UVB phototherapy and in the control group.
RESULTS: Compared with the control group, neutrophil count and NLR were significantly higher (p<0.001) in psoriasis patients before NB-UVB phototherapy. Serum endocan levels were significantly correlated with disease activity before treatment. There was no significant difference in NLR, serum endocan, and nesfatin-1 levels in psoriasis patients before and after NB-UVB phototherapy (p>0.05).
CONCLUSIONS: The current study shows that NLR was higher in psoriasis vulgaris patients when compared with the control group, whereas serum endocan and nesfatin-1 levels were not significantly different. In addition, NB-UVB phototherapy did not affect NLR, serum endocan, or nesfatin-1 levels. Further larger-scale studies are required on this subject.

Keywords: Calcium-Binding Proteins - blood, Biomarkers - blood, Adult, Case-Control Studies, DNA-Binding Proteins - blood, Lymphocytes - radiation effects, Neoplasm Proteins - blood, Nerve Tissue Proteins - blood, Neutrophils - radiation effects, Phototherapy - methods, Proteoglycans - blood, Psoriasis - therapy, Ultraviolet Therapy



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