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12 April 2016 : Clinical Research  

Neutrophil/Lymphocyte Ratio, Serum Endocan, and Nesfatin-1 Levels in Patients with Psoriasis Vulgaris Undergoing Phototherapy Treatment

Aybala Erek ToprakABCDEFG, Emin OzluDEF, Tugba Kevser UzuncakmakBD, Emre YalcınkayaB, Sadık SogutA, Ayşe Serap KaradagABCD

DOI: 10.12659/MSM.898240

Med Sci Monit 2016; 22:1232-1237

Abstract

BACKGROUND: Psoriasis is an autoimmune, inflammatory, and chronic disease. Recent studies have evaluated serum endocan and nesfatin-1 levels in patients with inflammatory disorders. The neutrophil-to-lymphocyte ratio (NLR) is an inflammatory marker currently used in many diseases. The aim of the present study was to evaluate NLR, serum endocan, and nesfatin-1 levels in psoriasis vulgaris before and after narrow-band ultraviolet B (NB-UVB) phototherapy treatment and compared to healthy controls.

MATERIAL AND METHODS: This study was conducted on a total of 88 cases, 39 of which had psoriasis vulgaris and 49 were healthy volunteers. Thirty-nine psoriasis vulgaris patients underwent NB-UVB phototherapy treatment for 3 months. NLR, serum endocan, and nesfatin-1 levels were measured in all psoriasis patients before and after NB-UVB phototherapy and in the control group.

RESULTS: Compared with the control group, neutrophil count and NLR were significantly higher (p<0.001) in psoriasis patients before NB-UVB phototherapy. Serum endocan levels were significantly correlated with disease activity before treatment. There was no significant difference in NLR, serum endocan, and nesfatin-1 levels in psoriasis patients before and after NB-UVB phototherapy (p>0.05).

CONCLUSIONS: The current study shows that NLR was higher in psoriasis vulgaris patients when compared with the control group, whereas serum endocan and nesfatin-1 levels were not significantly different. In addition, NB-UVB phototherapy did not affect NLR, serum endocan, or nesfatin-1 levels. Further larger-scale studies are required on this subject.

Keywords: Calcium-Binding Proteins - blood, Biomarkers - blood, Case-Control Studies, DNA-Binding Proteins - blood, Lymphocytes - radiation effects, Neoplasm Proteins - blood, Nerve Tissue Proteins - blood, Neutrophils - radiation effects, Phototherapy - methods, Proteoglycans - blood, Psoriasis - therapy, Ultraviolet Therapy

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750