Gremlin-1 Concentrations Are Correlated with the Severity of Knee Osteoarthritis
Jun Yi, Qunhua Jin, Bin Zhang, Xinqiu Wu, Dawei Ge
Department of Orthopaedics, Traditional Chinese Medicine Hospital, Shuyang, Jiangsu, China (mainland)
Med Sci Monit 2016; 22:4062-4065
DOI: 10.12659/MSM.897849
Available online: 2016-10-29
Published: 2016-10-29
BACKGROUND:
Gremlin-1, a bone morphogenetic protein (BMP) antagonist, is up-regulated in osteoarthritis (OA). Therefore, we aim to evaluate the correlation between gremlin-1 concentrations and the onset and severity of OA.
MATERIAL AND METHODS:
We performed this cross-sectional study in a population of 212 patients with knee OA and 125 healthy controls.
RESULTS:
Patients with knee OA had higher serum gremlin-1 concentrations than healthy controls. Serum and synovial fluid (SF) gremlin-1 concentrations increased according to advanced Kellgren-Lawrence grading stages.
CONCLUSIONS:
Serum and SF gremlin-1 concentrations are correlated with the onset and severity of knee OA.
Keywords: Biomarkers - blood, Case-Control Studies, Cross-Sectional Studies, Disease Progression, Intercellular Signaling Peptides and Proteins - metabolism, Osteoarthritis, Knee - metabolism, Severity of Illness Index, Synovial Fluid - metabolism, Up-Regulation
