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20 May 2016 : Animal Research  

Propofol Mitigates Learning and Memory Impairment After Electroconvulsive Shock in Depressed Rats by Inhibiting Autophagy in the Hippocampus

Ping LiAEF, Xue-chao HaoCF, Jie LuoC, Feng LvC, Ke WeiA, Su MinAE

DOI: 10.12659/MSM.897765

Med Sci Monit 2016; 22:1702-1708

Abstract

BACKGROUND: The present study explored the effects of propofol on hippocampal autophagy and synaptophysin in depression-model rats undergoing electroconvulsive shock (ECS).

MATERIAL AND METHODS: The rat depression model was established by exposing Sprague-Dawley rats to stress for 28 consecutive days. Forty rats were assigned randomly into the depression group (group D; no treatment), the ECS group (group E), the propofol group (group P), and the propofol + ECS group (group PE). Open field tests and sucrose preference tests were applied to evaluate the depression behavior; and Morris water maze tests were used to assess the learning and memory function of the rats. Western blotting was used to detect the expression of Beclin-1 and LC3-II/I; and ELISA was applied to assess the expression of synaptophysin.

RESULTS: Rats in group E and group PE scored higher in the open field and sucrose preference tests compared with those in group D. Furthermore, rats in group E also had a longer escape latency, a shorter space exploration time, and increased expression of Beclin-1, LC3-II/I, and synaptophysin. Compared with group E, rats in group PE possessed a shorter escape latency, a longer space exploration time, reduced expression of Beclin-1, LC3-II/I, and synaptophysin.

CONCLUSIONS: Propofol could inhibit excessive ECS-induced autophagy and synaptophysin overexpression in the hippocampus, thus protecting the learning and memory functions in depressed rats after ECS. The inhibitory effects of propofol on the overexpression of synaptophysin may result from its inhibitory effects on the excessive induction of autophagy.

Keywords: Depression - therapy, Autophagy - drug effects, Animals, Depressive Disorder - therapy, Disease Models, Animal, Electroconvulsive Therapy - methods, Hippocampus - drug effects, Learning - drug effects, Maze Learning - drug effects, Memory Disorders - etiology, Propofol - pharmacology, Random Allocation, Rats, Rats, Sprague-Dawley, Stress, Psychological - drug therapy, Synaptophysin - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750