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15 October 2016 : Animal Research  

Effect of Tripterygium Wilfordii Polyglycoside on Experimental Prostatitis Caused by Ureaplasma Urealyticum in Rats

Pingnan ShanBC, Zhiyong LuCD, Lihong YeABCD, Yaqin FangDE, Suhong TanEF, Guohong XuanFG, Jincheng RuAE, Liming MaoBG

DOI: 10.12659/MSM.897360

Med Sci Monit 2016; 22:3722-3726

Abstract

BACKGROUND: Prostatitis is a common and refractory urological disease with complicated etiology. Ureaplasma urealyticum (UU) has a close relationship with human urinary tract infection that can induce nonbacterial prostatitis. Tripterygium wilfordii polyglycoside (TWP) is a non-steroidal immune inhibitor that causes significant immune suppression and anti-inflammatory effects. Its role in prostatitis caused by UU has not yet been established. The aim of this study was to investigate the effect of TWP on UU-infected prostatitis in a rat model.

MATERIAL AND METHODS: UU-infected prostatitis SD model rats were randomly divided into 2 groups: the prostatitis group (model group) and the TWP treatment group (treatment group). At 7 days after treatment, prostate weight, leucocyte count, lecithin corpuscles, UU infection rate, and UU microbe count were compared between the 2 groups. Serum inflammatory cytokines TNF-α was determined by ELISA, and ICAM-1 and NF-κB expression were detected.

RESULTS: UU infection rate was 80% after modeling. The rat prostate weight and leucocyte count in the model group increased significantly, while lecithin corpuscles decreased. Compared with controls, inflammatory factor TNF-α, ICAM-1, and NF-κB expression were obviously higher (P<0.05). TWP markedly reduced prostate weight and leucocyte count, increased lecithin corpuscles, and decreased UU microbe count and TNF-α, ICAM-1, and NF-κB expression (P<0.05).

CONCLUSIONS: TWP can inhibit expression of inflammatory factors and may be useful in treating UU-infected prostatitis through reducing UU infection rate.

Keywords: Cytokines - blood, Glycosides - pharmacology, Intercellular Adhesion Molecule-1 - blood, NF-kappa B - blood, Prostatitis - microbiology, Random Allocation, Tripterygium - chemistry, Tumor Necrosis Factor-alpha - blood, Ureaplasma Infections - microbiology, Ureaplasma urealyticum - drug effects

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750