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26 February 2016 : Clinical Research

Increased Plasma miRNA-30a as a Biomarker for Non-Small Cell Lung Cancer

Ling SunBCEF, Yifan ChenBCE, Qiaoli SuBF, Xiaoju TangBC, Yasha LiangBC, Guowei CheA, Fengming LuoA

DOI: 10.12659/MSM.897330

Med Sci Monit 2016; 22:647-655

Abstract

BACKGROUND: MicroRNA (miRNA) is a small, non-coding RNA molecule which plays a role in the carcinogenesis and progression of cancers. Abnormal expression of miRNA in plasma has been found in some patients with malignant tumors.

MATERIAL AND METHODS: This study was conducted to investigate the expression of miRNA-30a in plasma of patients with non-small cell lung cancer (NSCLC). The plasma miRNA-30a in 87 patients with NSCLC, 20 patients with benign lung diseases, and 76 healthy subjects were measured by real-time PCR. The diagnostic value of miRNA-30a in NSCLC was evaluated via the ROC curve method.

RESULTS: Plasma miRNA-30a level was significantly higher in the NSCLC group compared with benign control and healthy control groups (P<0.01). No statistically significant difference was found in the expression level of miRNA-30a among various clinical pathologic features in NSCLC. ROC curve analysis showed that the specificity and sensitivity cut-off points were at 61.0% and 84.3% for NSCLC. The specificity and sensitivity values were 54.9% and 94.4%, respectively, in the analysis based on in-patients only.

CONCLUSIONS: All these results suggest that plasma miRNA-30a measurement may be a novel and noninvasive method for NSCLC preliminary screening and differential diagnosis.

Keywords: Biomarkers, Tumor - genetics, Carcinoma, Non-Small-Cell Lung - pathology, Cluster Analysis, Down-Regulation - genetics, Inpatients, Linear Models, Lung Neoplasms - pathology, MicroRNAs - genetics, ROC Curve

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750