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eISSN: 1643-3750

Correlation of Adrenomedullin Concentrations with Knee Osteoarthritis Grade

Linghua Liu, Ruokun Huang, Dezhang Ma, Wenjun Cheng, Wei Feng, Danmou Xing, Wusheng Kan, Zhihong Xiao

Department of Nursing, Hubei College of Chinese Medicine, Jingzhou, Hubei, China (mainland)

Med Sci Monit 2016; 22:2775-2778

DOI: 10.12659/MSM.896987

Available online: 2016-08-06

Published: 2016-08-06


BACKGROUND: Adrenomedullin, a recently identified myokine, has an anti-inflammatory effect. Therefore, we aimed to assess the correlation of adrenomedullin concentrations with the presence and grade of severity of knee osteoarthritis (OA).
MATERIAL AND METHODS: We recruited 187 knee OA patients and 109 healthy subjects. The severity of OA was evaluated using the Kellgren-Lawrence grading system.
RESULTS: Compared with the control group, the knee OA group revealed markedly higher adrenomedullin concentrations. Serum and synovial fluid (SF) adrenomedullin concentrations increased with increased KL grades.
CONCLUSIONS: Serum and SF adrenomedullin concentrations show a correlation with the severity of knee OA.

Keywords: Biomarkers - metabolism, Adrenomedullin - metabolism, Case-Control Studies, Cross-Sectional Studies, Osteoarthritis, Knee - pathology, Severity of Illness Index, Synovial Fluid - metabolism



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