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10 July 2016 : Clinical Research  

Massive Cerebrospinal Fluid Replacement Reduces Delayed Cerebral Vasospasm After Embolization of Aneurysmal Subarachnoid Hemorrhage

Liming GengADEF, Fei MaA, Yun LiuA, Yanchun MuA, Zhongmin ZouADEF

DOI: 10.12659/MSM.896879

Med Sci Monit 2016; 22:2404-2408

Abstract

BACKGROUND: Delayed cerebral vasospasm (DCVS) following aneurismal subarachnoid hemorrhage (SAH) is a leading cause of poor prognosis and death in SAH patients. Effective management to reduce DCVS is needed. A prospective controlled trial was conducted to determine if massive cerebrospinal fluid (CSF) replacement (CR) could reduce DCVS occurrence and improve the clinical outcome after aneurysmal SAH treated with endovascular coiling.

MATERIAL AND METHODS: Patients treated with endovascular coiling after aneurysmal SAH were randomly divided into a control group receiving regular therapy alone (C group, n=42) and a CSF replacement group receiving an additional massive CSF replacement with saline (CR group, n=45). CSF examination, head CT, DCVS occurrence, cerebral infarction incidence, Glasgow Outcome Scale prognostic score, and 1-month mortality were recorded.

RESULTS: The occurrence of DCVS was 30.9% in the C group and 4.4% in the CR group (P<0.005). The cerebral infarction incidences in the C and CR groups were 19.0% and 2.2% (P<0.05), respectively, 1 month after the treatments. Mortality was not significantly different between the 2 groups during the follow-up period.

CONCLUSIONS: Massive CR after embolization surgery for aneurysmal SAH can significantly reduce DCVS occurrence and effectively improve the outcomes.

Keywords: Cerebral Infarction - prevention & control, Cerebrospinal Fluid, Embolization, Therapeutic - methods, Glasgow Outcome Scale, Intracranial Aneurysm - therapy, Prospective Studies, Subarachnoid Hemorrhage - therapy, Tomography, X-Ray Computed, Vasospasm, Intracranial - prevention & control

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750