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10 September 2016 : Animal Research

Association of Chemerin and Vascular Endothelial Growth Factor (VEGF) with Diabetic Nephropathy

Shuhua LinBC, Jian TengABCD, Jixia LiCD, Fang SunDE, Dong YuanEF, Jing ChangFG

DOI: 10.12659/MSM.896781

Med Sci Monit 2016; 22:3209-3214

Abstract

BACKGROUND: Diabetic nephropathy (DN) is a common complication of diabetes, caused by diabetic microvascular lesions. The pathogenesis of DN is complicated, involving genetics, physics, chemistry, and environmental factors. Chemerin is a fat cell factor that participates in regulating inflammation. Vascular endothelial growth factor (VEGF) promotes vascular endothelial cell proliferation, differentiation, and angiogenesis. The relationship role of Chemerin and VEGF in DN is not fully understood.

MATERIAL AND METHODS: SD rats were randomly divided into 2 groups: the control group and the DN group. Streptozotocin was used to construct the DN model. Serum creatinine (Scr), blood urea nitrogen (BUN), and urine microalbumin (UAlb) were detected. Real-time PCR and Western blot were used to test Chemerin and VEGF mRNA and protein expression in kidney tissue. ELISA was performed to test TGF-β1, TNF-α, and INF-γ levels. The correlation of Chemerin and VEGF with renal function and inflammatory factors was analyzed.

RESULTS: DN group rats showed obviously increased Scr and BUN levels, and elevated TGF-β1, TNF-α, and INF-γ secretion (P<0.05). Compared with controls, Chemerin and VEGF were clearly overexpressed in the DN group (P<0.05). Chemerin and VEGF expression were positively correlated with inflammatory factors and renal function.

CONCLUSIONS: Chemerin and VEGF play important roles in DN by regulating inflammatory factors and renal function. They may be treated as indicators of DN.

Keywords: Diabetic Nephropathies - physiopathology, Animals, Chemokines - metabolism, Inflammation Mediators - metabolism, Intercellular Signaling Peptides and Proteins - metabolism, Kidney - physiopathology, Kidney Function Tests, Rats, Sprague-Dawley, Survival Analysis, Vascular Endothelial Growth Factor A - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750