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07 June 2016 : Hypothesis  

Potential Role of Reversion-Inducing Cysteine-Rich Protein with Kazal Motifs (RECK) in Regulation of Matrix Metalloproteinases (MMPs) Expression in Periodontal Diseases

Nian LiuABCDEF, Bin ZhouDEG, Guangxun ZhuAEFG

DOI: 10.12659/MSM.896546

Med Sci Monit 2016; 22:1936-1938

Abstract

ABSTRACT: Periodontal diseases are characterized by pathological destruction of extracellular matrix (ECM) of periodontal tissues. Matrix metalloproteinases (MMPs) are a significant part of the degradation of ECM. However, the regulation of MMPs expression level in periodontal diseases is as yet undetermined. RECK (reversion-inducing cysteine-rich protein with Kazal motifs), a novel membrane-anchored inhibitor of MMPs, could regulate the expressions of MMP-2, 9 and MT1-MMP as a cell surface-signaling molecule. Thus, we propose that RECK may play an important role in regulating MMPs in the ECM degradation of periodontal diseases. The RECK/MMPs signaling pathway could provide a new approach for prevention and treatment of RECK in periodontal diseases by blocking MMPs.

Keywords: GPI-Linked Proteins - metabolism, Extracellular Matrix - metabolism, Matrix Metalloproteinase 14 - metabolism, Matrix Metalloproteinase Inhibitors - metabolism, Matrix Metalloproteinases - metabolism, Periodontal Diseases - metabolism

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750