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01 June 2016 : Meta-Analysis  

Decoy Receptor 3 (DcR3) as a Biomarker of Tumor Deterioration in Female Reproductive Cancers: A Meta-Analysis

Mengtong JiangBCDEF, Xiaomiao LinCF, Rongquan HeCF, Xinggu LinCF, Lu LiangDF, Ruixue TangDF, Dandan XiongDF, Kanglai WeiF, Yiwu DangDF, Zhenbo FengF, Gang ChenABDEG

DOI: 10.12659/MSM.896226

Med Sci Monit 2016; 22:1850-1857

Abstract

BACKGROUND: DcR3 (decoy receptor 3) has been proposed be involved in development and prognosis of female reproductive cancers, including cervical cancer, ovarian cancer, and breast cancer. The purpose of this meta-analysis was to explore the evidence for the correlation between DcR3 and the clinicopathological characteristics, as well as the overall survival time, in female reproductive cancers.

MATERIAL AND METHODS: Relevant studies were searched for in PubMed, Wiley Online Library, Web of Science, Science Direct, Cochrane Central Register of Controlled Trials, Google Scholar, EMBASE, Ovid, LILACS, Chinese CNKI, Chong Qing VIP, Wan Fang, and China Biology Medicine disc up to 30 September 2015. Data on the relationship between DcR3 expression and TNM stage, differentiation, lymph node metastasis, age, and overall survival time were extracted. Pooled odds ratios (ORs) and 95% CIs (confidence intervals) were estimated by forest plot.

RESULTS: Twelve studies with 1127 patients met the inclusion criteria for this meta-analysis. Overexpression of DcR3 was significantly related to the risk of female reproductive cancers (OR=10.69, 95% CI: 6.33–18.05), TNM stage (OR=5.51, 95% CI: 2.83–10.71), differentiation (OR=4.16, 95% CI: 2.28–7.60), lymph node metastasis (OR=5.89, 95% CI: 3.16–10.9), age (OR=0.85, 95% CI: 0.51–1.44), and overall survival time (OR=1.84, 95% CI: 0.58–5.83). Subgroup analyses showed that overexpression of DcR3 in cervical, ovarian, and breast cancer all had similar relationships with these clinicopathological parameters.

CONCLUSIONS: Our meta-analysis suggests that overexpression of DcR3 may play vital roles in the tumorigenesis and deterioration of female reproductive cancers. However, the relationship between DcR3 expression and prognosis needs further investigation.

Keywords: Case-Control Studies, Breast Neoplasms - pathology, Biomarkers, Tumor - genetics, Genital Neoplasms, Female - pathology, Odds Ratio, Ovarian Neoplasms - pathology, Prognosis, Receptors, Tumor Necrosis Factor, Member 6b - genetics, Uterine Cervical Neoplasms - pathology

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Medical Science Monitor eISSN: 1643-3750
Medical Science Monitor eISSN: 1643-3750